Evidence map›Paper›PMID 41249195›Full record

ArticleNPJ biofilms and microbiomes2025

N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque.

Rakesh Sikdar, Mai V Beauclaire, Mark C Herzberg, Bruno P Lima, Mikael H Elias

Abstract read
In one paragraph

Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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  7. Review
4 · The record

Corrections and comments

  • Update of
    2024
5 · Who and what money

Authors and funding

5 authors.

Rakesh Sikdar *Biotechnology Institute, University of Minnesota, Saint Paul, MN, USA.
Mai V Beauclaire *Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Saint Paul, MN, USA.
Mark C HerzbergDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.
Bruno P LimaDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA. blima@umn.edu.
Mikael H EliasBiotechnology Institute, University of Minnesota, Saint Paul, MN, USA. mhelias@umn.edu.

Funding

TRAINING FOR FUTURE BIOTECHNOLOGY DEVELOPMENTT32GM008347 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SCHMIDT-DANNERT, CLAUDIA · 1990 to 2021
$11.0M
Unravelling the Importance of Bacterial Signaling using Specific Interference StrategiesR35GM133487 · NIGMS · UNIVERSITY OF MINNESOTA · PI Mikael H Elias · 2019 to 2026
$2.7M
Regulation of Surface Protein Presentation on Streptococcus gordoniiR01DE025618 · NIDCR · UNIVERSITY OF MINNESOTA · PI HERZBERG, MARK C · 2016 to 2020
$2.2M
Investigating the role of lipoteichoic acid in surface protein presentationK08DE027705 · NIDCR · UNIVERSITY OF MINNESOTA · PI LIMA, BRUNO P · 2018 to 2022
$620k
The role of protein acetylation in Streptococcus gordonii biofilmsR03DE031337 · NIDCR · UNIVERSITY OF MINNESOTA · PI LIMA, BRUNO P · 2022 to 2023
$310k
NIDCR NIH HHS K08 DE027705NIDCR NIH HHS K08DE027705NIDCR NIH HHS R01 DE025618NIDCR NIH HHS R01DE025618NIDCR NIH HHS R03 DE031337NIGMS NIH HHS R35 GM133487NIGMS NIH HHS R35GM133487NIGMS NIH HHS T32 GM008347NIH HHS T32GM008347
6 · The paper itself

Abstract

Dental plaque is a complex oral biofilm responsible for periodontal diseases. Bacterial biofilms are often regulated by Quorum Sensing (QS) mediated by N-acyl homoserine lactones (AHLs). While their presence and roles in oral microbiota have been debated, emerging evidence suggests AHLs influence oral biofilm development. AHLs are detectable in a microbial community derived from human dental plaque cultured under 5% CO

Indexed as

Acyl-ButyrolactonesBacteriaBiofilmsDental PlaqueMicrobiotaQuorum SensingSignal TransductionAnaerobiosisHumansAcyl-Butyrolactones

Identifiers

PMID41249195
PMCPMC12623758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.