ArticleNPJ science of food2025
Single-cell RNA sequencing reveals that kimchi dietary intervention modulates human antigen-presenting and CD4⁺ T cells.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Kimchi, a traditional Korean fermented food, is recognized for its metabolic benefits; however, its effects on human immune function remain poorly defined. In this study, we performed single-cell RNA-seq on peripheral blood mononuclear cells from 13 overweight adults using a paired pre/post design in a 12-week randomized, double-blind, placebo-controlled trial. The participants consumed a placebo, spontaneously fermented kimchi powder, or starter culture-fermented kimchi powder. Kimchi enhanced intercellular signaling mediated by antigen-presenting cells, increased antigen uptake, and promoted the upregulation of MHC class II-related genes through the JAK/STAT1-CIITA axis. Single-cell trajectory analysis revealed accelerated CD4
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