Evidence map›Paper›PMID 41249165›Full record

ArticleNature communications2025

Impact of a transient neonatal visual deprivation on the development of the ventral occipito-temporal cortex in humans.

Stefania Mattioni, Mohamed Rezk, Xiaoqing Gao, Junghyun Nam, Zhong-Xu Liu, Remi Gau, Valérie Goffaux, Andrea I Costantino, Hans Op de Beeck, Terri Lewis and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stefania MattioniDepartment of Experimental Psychology & Center for Cognitive Neuroscience (CCN), UGent, Gent, Belgium. stefania.mattioni@ugent.be.ORCID http://orcid.org/0000-0001-8279-6118
Mohamed RezkInstitute for Research in Psychology (IPSY) & Neuroscience (IoNS), UCLouvain, Louvain-la-Neuve and Brussels, Belgium.
Xiaoqing GaoCenter for Psychological Sciences, Zhejiang University, Zhejiang, China.
Junghyun NamThe Rotman Research Institute in Baycrest Health Sciences, University of Toronto, Toronto, ON, Canada.
Zhong-Xu LiuDepartment of Behavioral Sciences, University of Michigan-Dearborn, Dearborn, MI, USA.ORCID http://orcid.org/0000-0002-0304-3271
Remi GauInstitute for Research in Psychology (IPSY) & Neuroscience (IoNS), UCLouvain, Louvain-la-Neuve and Brussels, Belgium.ORCID http://orcid.org/0000-0002-1535-9767
Valérie GoffauxInstitute for Research in Psychology (IPSY) & Neuroscience (IoNS), UCLouvain, Louvain-la-Neuve and Brussels, Belgium.
Andrea I CostantinoDepartment of Brain & Cognition, Leuven Brain Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-8481-3142
Hans Op de BeeckDepartment of Brain & Cognition, Leuven Brain Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-2250-212X
Terri LewisDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada.
Daphne MaurerDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada.
Olivier CollignonInstitute for Research in Psychology (IPSY) & Neuroscience (IoNS), UCLouvain, Louvain-la-Neuve and Brussels, Belgium. olivier.collignon@uclouvain.be.ORCID http://orcid.org/0000-0003-1882-3550

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How does sensory experience shape the development of the visual brain? To answer this eluding question, we examine brain responses to visual categories in a rare group of cataract-reversal individuals who experienced a short transient period of early blindness. Encoding of low-level visual properties is impaired in the early visual cortex (EVC) of cataract-reversal participants, whereas categorical responses in downstream ventral occipito-temporal cortex (VOTC) are preserved. In controls, degrading visual input to mimic the visual deficits of cataracts produces cascading disruptions extending from EVC to VOTC, unlike in the cataract group. A deep neural network trained on altered visual input reproduces this dissociation, supporting the brain findings. These results demonstrate that while EVC is permanently affected by early deprivation, categorical coding in VOTC shows resilience, highlighting different sensitive periods for specific brain regions and computations.

Indexed as

BlindnessCataractOccipital LobeSensory DeprivationTemporal LobeVisual CortexAdultFemaleHumansInfant, NewbornMagnetic Resonance ImagingMalePhotic StimulationVisual PerceptionYoung Adult

Identifiers

PMID41249165
PMCPMC12624091

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.