Evidence map›Paper›PMID 41248900›Full record

ArticleJornal de pediatria

Association of blood transfusion-related di-(2-ethylhexyl) phthalate exposure with gut microbiota alterations in preterm infants.

Yung-Ning Yang, Yu-Chen S H Yang, San-Nan Yang, Ying-Yu Chen, Hung-Yun Lin, Jau-Ling Suen

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Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yung-Ning YangI-Shou University, E-DA Hospital, Department of Pediatrics, Kaohsiung, Taiwan; I-Shou University, College of Medicine, School of Medicine, Kaohsiung, Taiwan.
Yu-Chen S H YangTaipei Medical University, Office of Human Research, Joint Biobank, Taipei, Taiwan; Taipei Medical University, College of Nutrition, Graduate Institute of Metabolism and Obesity Sciences, Taipei, Taiwan.
San-Nan YangI-Shou University, E-DA Hospital, Department of Pediatrics, Kaohsiung, Taiwan; I-Shou University, College of Medicine, School of Medicine, Kaohsiung, Taiwan.
Ying-Yu ChenI-Shou University, E-DA Hospital, Department of Pediatrics, Kaohsiung, Taiwan; Kaohsiung Medical University, College of Medicine, Graduate Institute of Medicine, Kaohsiung, Taiwan.
Hung-Yun LinTaipei Medical University, College of Medical Science and Technology, Graduate Institute of Cancer Molecular Biology and Drug Discovery, Taipei, Taiwan; Taipei Medical University, Wan Fang Hospital, Cancer Center, Taipei, Taiwan; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, USA; Taipei Medical University, TMU Research Center of Cancer Translational Medicine, Taipei, Taiwan; Taipei Medical University, Taipei Medical University Hospital, Traditional Herbal Medicine Research Center, Taipei, Taiwan.
Jau-Ling SuenKaohsiung Medical University, College of Medicine, Graduate Institute of Medicine, Kaohsiung, Taiwan; Kaohsiung Medical University, Research Center for Precision Environmental Medicine, Kaohsiung, Taiwan; Kaohsiung Medical University Hospital, Department of Medical Research, Kaohsiung, Taiwan. Electronic address: jlsuen@kmu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAvoiding early-life exposure to environmental endocrine disruptors (EDCs) is critical for neonatal growth and long-term health. However, exposure to Di-(2-ethylhexyl) phthalate (DEHP), a typical EDC and plasticizer, is unavoidable in neonatal intensive care units due to contact with polyvinyl chloride medical devices.

methodsThis study examined the impact of DEHP exposure through blood transfusion on gut microbiota development in preterm infants. To address this aim, the authors conducted a prospective cohort study, enrolling preterm infants between May 1, 2016, and March 30, 2021, who had not received blood transfusions or antibiotic treatment for at least seven consecutive days prior to enrollment. Fecal samples collected before and after transfusion underwent 16S ribosomal RNA gene-based next-generation sequencing analysis, while DEHP levels were measured in post-transfusion blood products. The average DEHP level in these products was 0.072 ± 0.03 mg/mL.

resultsInitial analysis of 23 preterm infants (including five recruited twice) indicated that blood transfusion did not significantly alter bacterial composition and diversity. However, when examining recruitment events by postmenstrual age (PMA) or days of life (DOL), a significant increase in Enterococcus abundance was observed in both the lower PMA and younger DOL groups.

conclusionsThese findings suggest a possible association between early-life DEHP exposure via blood transfusion and altered gut microbiota. Further studies are needed to clarify causality and long-term health implications.

Indexed as

Diethylhexyl PhthalateEndocrine DisruptorsGastrointestinal MicrobiomeInfant, PrematurePlasticizersTransfusion ReactionFecesFemaleHumansInfant, NewbornMaleProspective StudiesDiethylhexyl PhthalateEndocrine DisruptorsPlasticizersBlood transfusionDi-(2-ethylhexyl) phthalateEnterococcusGut Microbiota

Identifiers

PMID41248900
PMCPMC12704293

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.