Evidence map›Paper›PMID 41248279›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

An adipo-osteoprogenitor population in the endosteal niche contributes to bone and fat formation in adult mouse bone marrow.

Xueyang Liao, Jasmin Koehnken Sawall, Rebecca Seeley, Fangfang Song, Xing Ji, Xiaobin Liu, Chao Song, Fanxin Long

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xueyang LiaoDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.ORCID 0000-0001-7876-3129
Jasmin Koehnken SawallDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.ORCID 0009-0005-2750-8108
Rebecca SeeleyDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Fangfang SongDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Xing JiDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.ORCID 0009-0002-5794-6078
Xiaobin LiuDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Chao SongDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Fanxin LongDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.ORCID 0000-0001-9785-5379

Funding

Illuminating adipo-osteoprogenitors in the bone marrowR01AG077911 · NIA · CHILDREN'S HOSP OF PHILADELPHIA · PI Fanxin Long · 2023 to 2026
$1.8M
NIA NIH HHS R01 AG077911
6 · The paper itself

Abstract

The adult bone marrow houses progenitors for both osteoblasts and adipocytes, but their precise molecular identity remains to be fully elucidated. Previous studies indicate that Lepr

Indexed as

AdipocytesBone MarrowBone Marrow CellsOsteoblastsOsteogenesisAdipogenesisAdiponectinAnimalsCell DifferentiationMesenchymal Stem CellsMiceMice, Inbred C57BLSp7 Transcription FactorStem Cell NicheAdiponectinAdipoq protein, mouseSp7 protein, mouseSp7 Transcription Factoradipocytebonedifferentiationosteoblastprogenitor cells

Identifiers

PMID41248279
PMCPMC12663985

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.