Evidence map›Paper›PMID 41248127›Full record

ArticleOncology2026

Selective Tumor Cytotoxicity via Singlet Oxygen: Investigating Eosinophil Peroxidase and Myeloperoxidase in Cancer Therapy.

Junnan Liu, Robert C Allen, Jackson Thomas Stephens, Haojie Huang, Paras Shah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Junnan LiuDepartment of Urology, Mayo Clinic, Rochester, Minnesota, USA.
Robert C AllenCreighton University School of Medicine, Omaha, Nebraska, USA.
Jackson Thomas StephensExoxemis, Inc., Little Rock, Arkansas, USA.
Haojie HuangDepartment of Urology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA, huanghaojie@zju.edu.cn.
Paras ShahDepartment of Urology, Mayo Clinic, Rochester, Minnesota, USA, shah.paras@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: Eosinophil peroxidase (EPO) and myeloperoxidase (MPO) are large, cationic enzymes secreted by granulocytes that bind preferentially to negatively charged cancer cell membranes generated by Warburg metabolism. In the presence of halide cofactors and hydrogen peroxide (H

methodsHuman bladder cancer cell lines (5637, T24) and normal urothelial cells (SV-HUC1) were treated with porcine EPO or porcine MPO aggregate formulations in acidic medium (pH 5.3). Activation occurred when 10 millimolar (mM) H

resultsAggregate formulations selectively eliminated bladder cancer cells while sparing SV-HUC1. IC

conclusionSelective cytotoxicity arises from concurrent enzyme binding and 1O

Indexed as

Eosinophil PeroxidasePeroxidaseSinglet OxygenUrinary Bladder NeoplasmsAnimalsCell Line, TumorCell SurvivalDNA DamageHumansHydrogen PeroxideEosinophil PeroxidaseHydrogen PeroxideMPO protein, humanPeroxidaseSinglet OxygenAntineoplastic effectBladder cancerHaloperoxidase

Identifiers

PMID41248127
PMCPMC12758891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.