The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming.
Zachary W Grimmett, Rongli Zhang, Hua-Lin Zhou, Qiuying Chen, Dawson Miller, Zhaoxia Qian, Justin Lin, Riti Kalra, Steven S Gross, Walter J Koch and 2 more
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Zachary W GrimmettMedical Scientist Training Program, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0000-0003-3820-2049
Rongli ZhangInstitute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States.
Hua-Lin ZhouInstitute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States.
Dawson MillerDepartment of Pharmacology, Weill Cornell Medicine, New York, United States.
Zhaoxia QianInstitute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States.
Justin LinInstitute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States.
Riti KalraInstitute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States.
Steven S GrossDepartment of Pharmacology, Weill Cornell Medicine, New York, United States.
Walter J KochDepartment of Surgery, Duke University School of Medicine, Durham, United States.
Richard T PremontInstitute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0000-0002-8053-5026
Jonathan S StamlerInstitute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0000-0002-6866-1572
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
S-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2021 to 2025
$12.0M
Restoration and Function of S-Nitrosothiol in Stored BloodR01HL126900 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JONATHAN S. STAMLER · 2016 to 2026
$5.0M
Novel Regulation of Renal Function by S-NitrosylationR01DK119506 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI JONATHAN S. STAMLER, Hualin Zhou · 2018 to 2026
$3.7M
Role of S-Nitrosylation on Beta-Adrenergic Signaling in Cardiac Injury and RepairR01HL157151 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KOCH, WALTER J., STAMLER, JONATHAN S. · 2021 to 2024
$2.8M
Metabolic remodeling of skeletal muscle in mitochondrial myopathiesR01AR076029 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, QIUYING, D'AURELIO, MARILENA · 2020 to 2024
$2.7M
Metabolic Landscape and Mitochondrial ROS Balance in Brain Ischemia/ReperfusionR01NS131322 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Alexander Galkin, Steven S Gross · 2024 to 2026
$1.6M
Gut Microbe-Derived Nitric Oxide As A Signal To Host: Role In Normal Physiology And In DiseaseR01DK128347 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI SETH, PUNEET, STAMLER, JONATHAN S. · 2021 to 2024
$1.4M
American Heart Association 19PABH134580006National Heart Lung and Blood Institute HL126900National Heart Lung and Blood Institute HL157151National Heart Lung and Blood Institute HL158507NHLBI NIH HHS P01 HL158507NHLBI NIH HHS R01 HL126900NHLBI NIH HHS R01 HL157151NIAMS NIH HHS AR076029NIAMS NIH HHS R01 AR076029NIDDK NIH HHS DK119506NIDDK NIH HHS DK128347NIDDK NIH HHS R01 DK119506NIDDK NIH HHS R01 DK128347NIGMS NIH HHS GM007250-44NIGMS NIH HHS T32 GM007250NINDS NIH HHS NS131322NINDS NIH HHS R01 NS131322
6 · The paper itself
Abstract
Acute myocardial infarction (MI) is a leading cause of morbidity and mortality, and therapeutic options remain limited. Endogenously generated nitric oxide (NO) is highly cardioprotective, but protection is not replicated by nitroso-vasodilators (e.g., nitrates, nitroprusside) used in clinical practice, highlighting specificity in NO-based signaling and untapped therapeutic potential. Signaling by NO is mediated largely by
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming. · full record | OpenQuestion