Evidence map›Paper›PMID 41247772›Full record

ReviewHuman reproduction (Oxford, England)2026

New models of implantation: towards a whole better than the sum of parts.

T M Rawlings, S A Guttridge, E S Lucas

Abstract readReview
In one paragraph

Review in Human reproduction (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

T M RawlingsLoke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
S A GuttridgeDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.ORCID 0009-0005-3229-4343
E S LucasDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.ORCID 0000-0002-8571-8921

Funding

Academy of Medical Sciences Springboard SBF0010\1091Next-Generation Fellowship at the Loke Centre for Trophoblast Research, University of Cambridge
6 · The paper itself

Abstract

Recent advances in the development of stem-cell-based embryo models and endometrial assembloids have fuelled understanding of their respective biology. However, a faithful combined approach is required to truly advance our understanding of implantation processes. This mini-review considers the most recent developments in producing reliable in vitro models of the human endometrium and human embryo, and the next steps required to combine their respective potential. While the fundamental biology of implantation is the primary driver of in vitro model development, the combined effort of embryo and endometrial models to generate new models of implantation provides the opportunity to manipulate either compartment to further understand the aetiologies of reproductive dysfunction. Through combining both systems, their efforts are symbiotic, each extending the relevance and utility of their counterpart to generate a whole greater than the sum of its parts.

Indexed as

Embryo ImplantationEndometriumModels, BiologicalFemaleHumansPregnancyblastoidearly pregnancyembryohuman endometriumimplantationin vitro modelsstem-cell-based embryo model

Identifiers

PMID41247772
PMCPMC12864150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.