ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2025
Sex differences in central salt sensing in the human brain.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Reply to Bie.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
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7 authors.
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Abstract
In preclinical models, the organum vasculosum of the lamina terminalis (OVLT) and subfornical organ (SFO) sense changes in serum sodium chloride (NaCl) concentration and mediate NaCl-induced changes in sympathetic nerve activity, vasopressin (AVP), thirst, and blood pressure (BP). In humans, brain imaging studies have shown that acute hypernatremia alters the activity or functional connectivity of the SFO and OVLT. However, no studies have investigated whether there are sex differences in central NaCl sensing in humans, which could underlie sex differences in neurohumoral responses to hypernatremia. Therefore, the purpose of this study was to test the hypothesis that acute relative hypernatremia would increase resting-state functional connectivity between NaCl-sensing brain regions and that these responses would be greater in men. Thirty-two young adults (17 men/15 women) underwent resting-state functional magnetic resonance imaging (fMRI) at baseline and during a 30-min intravenous hypertonic saline infusion. We performed a seed-to-seed functional connectivity analysis. Despite similar increases in serum sodium, thirst, systolic BP, and plasma AVP between the sexes, there was a time × sex interaction (
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