Evidence map›Paper›PMID 41247659›Full record

ArticleOdontology2026

Multifunctional aloe vera-based biomaterial for vital pulp therapy: an in vivo evaluation.

Sharon S Namazi, Pedro Henrique Chaves de Oliveira, Neville J McDonald, Bruno Cavalcanti, Hajime Sasaki, Marco C Bottino, Renan Dal-Fabbro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sharon S NamaziDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, 1011 N. University Ave, Ann Arbor, MI, 48109, USA.
Pedro Henrique Chaves de OliveiraDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, 1011 N. University Ave, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-1593-7926
Neville J McDonaldDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, 1011 N. University Ave, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-2316-6631
Bruno CavalcantiDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, 1011 N. University Ave, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-0455-4823
Hajime SasakiDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, 1011 N. University Ave, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0003-3336-2537
Marco C BottinoDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, 1011 N. University Ave, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0001-8740-2464
Renan Dal-FabbroDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, 1011 N. University Ave, Ann Arbor, MI, 48109, USA. renandf@umich.edu.ORCID http://orcid.org/0000-0002-4125-8441

Funding

Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication ApproachR01DE031476 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Marco C Bottino · 2022 to 2026
$2.6M
Multi-functional 3D Printed Dental Implants for Preventing Peri-implantitisR01DE033364 · NIDCR · CLEVELAND STATE UNIVERSITY · PI Prabaha Sikder · 2024 to 2026
$1.9M
NIDCR NIH HHS R01 DE031476NIDCR NIH HHS R01DE031476NIDCR NIH HHS R01 DE033364NIDCR NIH HHS R01DE033364
6 · The paper itself

Abstract

This study aimed to evaluate the effects of Gelatin methacryloyl/Aloe vera (GelMA/AV) scaffolds, both alone and in combination with mineral trioxide aggregate (MTA), on pulp inflammatory response and mineralized tissue formation in a rat model of pulp exposure. GelMA/AV nanofibers (70:30) were fabricated via electrospinning and photocrosslinked. Twenty-four rats were randomly assigned to three groups (n = 8/ group): GelMA/AV, GelMA/AV + MTA, and MTA (control). Following pulp exposure of the first upper molars (n = 2/animal), the materials were placed over the exposed pulp as the pulp capping agent, and MTA was applied or not, depending on the group. The cavities were then sealed with glass ionomer. Animals were euthanized at 7 or 28 days post-procedure for histological, immunohistochemical, and micro-computed tomography (micro-CT) analyses. Data were analyzed using one-way or two-way ANOVA at a 5% significance level. Micro-CT analysis at 28 days revealed new hard tissue formation in the pulp chamber across all groups. GelMA/AV + MTA demonstrated comparable mineralized volume and tissue mineral density to MTA. Histologically, the GelMA/AV + MTA group exhibited a significantly lower cell count than the MTA and GelMA/AV groups at 28 days. However, for macrophage polarization, the GelMA/AV + MTA exhibited a similar expression of CD163-positive (M2) and iNOS-positive (M1) cells compared to the MTA. Lastly, GelMA/AV + MTA also showed expression of nestin and DMP1 at 28 days, indicating active mineralization. In conclusion, a thin GelMA/AV sublayer beneath MTA preserves MTA-driven mineralization but does not reduce pulp inflammation or enhance mineralization beyond MTA in this model. Optimization of AV dosing/formulation and longer follow-up are necessary before clinical translation.

Indexed as

AloeBiocompatible MaterialsDental Pulp CappingAluminum CompoundsAnimalsCalcium CompoundsDental PulpDrug CombinationsGelatinImmunohistochemistryMaleOxidesPulp Capping and Pulpectomy AgentsRatsSilicatesTissue ScaffoldsAluminum CompoundsBiocompatible MaterialsCalcium CompoundsDrug CombinationsGelatinmineral trioxide aggregateOxidesPulp Capping and Pulpectomy AgentsSilicatesAloe veraElectrospinningGelatin methacryloylRegenerative endodontics

Identifiers

PMID41247659
PMCPMC13011884

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.