Evidence map›Paper›PMID 41247652›Full record

ArticleCurrent medical science2025

Virulence and Genomic Profiles of Klebsiella pneumoniae Isolated from Pediatric Patients in Henan, China (2021-2023).

Yue Qiu, Chu-Ning Wang, Jun-Wen Yang, Kai-Jie Gao, Jun-Zhen Zhu, Bao-Liang Wang, He Tian, Yi-Bing Cheng, Mei Zeng

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Article in Current medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yue Qiu *Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
Chu-Ning Wang *Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
Jun-Wen YangDepartment of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Kai-Jie GaoDepartment of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Jun-Zhen ZhuDepartment of Emergency, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Bao-Liang WangDepartment of Emergency, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
He TianDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
Yi-Bing ChengDepartment of Emergency, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital Zhengzhou Children's Hospital, Zhengzhou, 450018, China. 13703829317@163.com.
Mei ZengDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China. zengmei@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate the virulence characteristics of Klebsiella pneumoniae (KP) strains isolated from children to analyze the genetic relatedness between pediatric and local adult CRKP isolates and to identify clinical risk factors associated with high-risk strains.

methodsKP strains and corresponding clinical data were collected at a tertiary provincial children's hospital in Henan province from January 2021 to May 2023. The molecular and clinical characteristics of pediatric carbapenem-resistant KP (CRKP) strains were analyzed. Genomic data from local adult isolates were integrated, and the virulence profiles of pediatric and adult isolates were compared. Clinical risk factors for isolating high-risk strains were initially screened via LASSO regression and then evaluated via multivariate binomial regression.

resultsAmong the 205 collected KP isolates, 87 (42.4%) were CRKP, and 118 (57.6%) were carbapenem-sensitive KP (CSKP). The predominant carbapenem resistance gene was bla

conclusionsThe ST11-KL47-KPC2 genotype was the predominant CRKP isolate in pediatric patients. The close genomic relatedness between pediatric and adult CRKP isolates suggests a common ancestor that has disseminated across populations. The high prevalence and clonal transmission of pediatric iuc

Indexed as

Klebsiella InfectionsKlebsiella pneumoniaeAdolescentAdultAnti-Bacterial AgentsCarbapenemsChildChild, PreschoolChinaFemaleHumansInfantMaleMicrobial Sensitivity TestsVirulenceVirulence FactorsAnti-Bacterial AgentsCarbapenemsVirulence FactorsCarbapenem-resistant Klebsiella pneumoniaeChildrenGenomic epidemiologyHypervirulent genesVirulence

Identifiers

PMID41247652
PMCPMC12748107

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