Evidence map›Paper›PMID 41247630›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2025

Light-induced interaction of anthraquinone derivative with Guanosine monophosphate: molecular mechanism and implication in cytotoxicity.

Maya Ulyanova, Alina Arkhipova, Simon Babenko, Olga Kartina, Olga Selyutina, Nikolay Polyakov

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Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maya UlyanovaInstitute of Chemical Kinetics and Combustion, Institutskaya St., 3, 630090, Novosibirsk, Russia.
Alina ArkhipovaInstitute of Chemical Kinetics and Combustion, Institutskaya St., 3, 630090, Novosibirsk, Russia.
Simon BabenkoInstitute of Chemical Kinetics and Combustion, Institutskaya St., 3, 630090, Novosibirsk, Russia.
Olga KartinaInstitute of Chemical Kinetics and Combustion, Institutskaya St., 3, 630090, Novosibirsk, Russia.
Olga SelyutinaInstitute of Chemical Kinetics and Combustion, Institutskaya St., 3, 630090, Novosibirsk, Russia. olga.gluschenko@gmail.com.
Nikolay PolyakovInstitute of Chemical Kinetics and Combustion, Institutskaya St., 3, 630090, Novosibirsk, Russia.

Funding

Russian Science Foundation 25-23-00243
6 · The paper itself

Abstract

Photoinduced reactions between photosensitizers and nucleic acids represent a fundamental mechanism in photodynamic therapy (PDT), primarily involving light-mediated oxidative damage to DNA. This study elucidates the interaction of a novel anthraquinone derivative, 2-phenyl-4-(butylamino)naphtho[2,3-h]quinoline-7,12-dione (Q1), with nucleotides using a combination of NMR spectroscopy, chemically induced dynamic nuclear polarization (CIDNP), and molecular dynamics simulations. We demonstrate that Q1 forms complexes with guanosine (GMP), adenosine (AMP), and cytidine (CMP) monophosphates in the dark, with the highest stability constant observed for the Q1/GMP complex. Upon photoexcitation, electron transfer occurs exclusively from GMP to Q1, generating a semiquinone radical anion and a neutral guanyl radical. The CIDNP data allowed for an estimation of the triplet state energy of Q1, E

Indexed as

AnthraquinonesAntineoplastic AgentsGuanosine MonophosphateLightPhotosensitizing AgentsCell Line, TumorCell SurvivalDrug Screening Assays, AntitumorHumansMolecular Dynamics SimulationMolecular StructureAnthraquinonesAntineoplastic AgentsGuanosine MonophosphatePhotosensitizing AgentsAnthraquinone derivativesAnti-proliferative activityCIDNPElectron transferGuanosine monophosphateMolecular dynamics.NMR

Identifiers

PMID41247630

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.