Evidence map›Paper›PMID 41247599›Full record

ArticleAnnals of surgical oncology2026

Prediction of Tracheobronchial Invasion in ycT3 Esophageal Cancer Using Contact Angle on Preoperative CT Images: A Multicenter Analysis.

Tomonori Nakanoko, Tetsuro Kawazoe, Kosuke Hirose, Qingjiang Hu, Yasuo Tsuda, Yuki Shin, Keita Natsugoe, Naomichi Koga, Sho Nambara, Kensuke Kudou and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Tomonori NakanokoDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan. nakanoko.tomonori.186@m.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0001-6486-9889
Tetsuro KawazoeDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.
Kosuke HiroseDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.
Qingjiang HuDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.
Yasuo TsudaDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.
Yuki ShinDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.
Keita NatsugoeDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.
Naomichi KogaDepartment of Gastroenterological Surgery, NHO Kyushu Cancer Center, Fukuoka, Japan.
Sho NambaraDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.
Kensuke KudouDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.
Koji AndoDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.
Yasue KimuraDepartment of Gastroenterological Surgery, NHO Kyushu Cancer Center, Fukuoka, Japan.
Mizuki NinomiyaDepartment of Surgery, Iizuka Hospital, Fukuoka, Japan.
Eiji OkiDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.
Tomoharu YoshizumiDepartment of Surgery and Science, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIf esophageal cancer extensively contacts the tracheobronchus (TB), a pathologic resection margin (pRM) cannot be reliably predicted. An objective diagnosis based on preoperative computed tomography (CT) is challenging because TB deformity is not necessarily caused by tumor invasion. It also may result from external compression by the tumor itself.

methodsAcross three institutions, 100 esophageal cancer patients with a diagnosis of ycT3, characterized by contact with the TB without apparent invasion, were enrolled. This study evaluated the relationship between the degree of contact angle (CA) and the pathologic outcomes of curative resection.

resultsPatients with positive resection margins (pRM1) had a significantly larger CA than those with negative margins (pRM0) (130° vs. 93°; P = 0.0002). Receiver operating characteristic (ROC) curve analysis identified an optimal CA cutoff of 125° for predicting pRM1 (sensitivity, 63%; specificity, 87%; area under the curve [AUC], 0.76). In all patients, CA ≥ 125° cases had a poorer prognosis (median survival time [MST]: CA ≥ 125° cases [11.0 months] vs CA < 125° cases [33.0 months]; hazard ratio [HR], 1.83; 95% confidence interval [CI], 1.05-3.20; P = 0.03). In neoadjuvant chemotherapy (NAC) cases, CA ≥ 125° had a poorer prognosis than < 125° cases (MST, 6.5 vs. 32.0 months; HR, 2.50; 95 % CI, 1.19-5.23; P = 0.02).

conclusionThe CA measured on preoperative CT may serve as a useful predictive indicator for curative pathologic resection in ycT3 esophageal cancer.

Indexed as

BronchiBronchial NeoplasmsEsophageal NeoplasmsTomography, X-Ray ComputedTracheaAdultAgedEsophagectomyFemaleFollow-Up StudiesHumansMaleMargins of ExcisionMiddle AgedNeoplasm InvasivenessPreoperative CareBorderline ResectableContact AngleCurative ResectionEsophageal CancerTracheal-Bronchial Contact

Identifiers

PMID41247599

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.