Evidence map›Paper›PMID 41247506›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Plasmacytoid dendritic cell clusters are associated with poor prognosis in chronic myelomonocytic leukemia.

Deepika Kumar, Wei Cheng, Lisa Lin, Philipp W Raess, Wei Xie, Jahg Wong, Parnaz Daneshpajouhnejad, Lamiaa A Fathalla, Elizabeth A Morgan, Adam Bagg and 3 more

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Deepika KumarDepartment of Pathology, Yale University, New Haven, CT, USA.
Wei ChengDepartment of Biostatistics, School of Public Health, Yale University, New Haven, CT, USA.
Lisa LinDepartment of Statistics and Data Science, Yale University, New Haven, CT, USA.
Philipp W RaessDepartment of Pathology and Laboratory Medicine, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
Wei XieDepartment of Pathology and Laboratory Medicine, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
Jahg WongDepartment of Pathology, University of Montreal Faculty of Medicine, University of Montreal Hospital Center, Montreal, QC, Canada.
Parnaz DaneshpajouhnejadDivision of Hematopathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lamiaa A FathallaDivision of Hematopathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Elizabeth A MorganDepartment of Pathology, Brigham & Women's Hospital/Harvard Medical School, Boston, MA, USA.
Adam BaggDivision of Hematopathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Robert HasserjianDepartment of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Samuel G KatzDepartment of Pathology, Yale University, New Haven, CT, USA.
Mina L XuDepartment of Pathology, Yale University, New Haven, CT, USA. mina.xu@yale.edu.ORCID http://orcid.org/0000-0001-9513-245X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic myelomonocytic leukemia (CMML) is associated with high rates of transformation to acute myeloid leukemia (AML) and poor overall survival. Plasmacytoid dendritic cell (pDC) proliferations in bone marrow biopsies have been proposed to be prognostically significant in CMML. In this multi-institutional study, we quantified pDC clusters in bone marrow biopsies of patients with CMML by interferon regulatory factor 8 (IRF8) immunohistochemical staining performed in separate laboratories and demonstrated the association of pDC clusters with overall survival. Two hundred five newly diagnosed CMML cases were scored for the presence of prominent pDC clusters, which were detected in 37 cases (18%). The median overall survival (OS) was 15.1 months for patients with pDC clusters versus 30.1 months for those without pDC clusters (p = 0.021 log-rank test, Kaplan-Meier analysis). We propose using IRF8 immunohistochemistry in CMML bone marrow evaluation.

Indexed as

Chronic myelomonocytic leukemiaIRF8Plasmacytoid dendritic cell

Identifiers

PMID41247506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.