ArticleClinical research in cardiology : official journal of the German Cardiac Society2025
Systematic review and meta-analysis of side effects and severe complications caused by intracoronary pressure measurement.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- The Contemporary Role of Intracoronary Physiological Assessment: Fractional Flow Reserve, Non-Hyperemic Pressure Ratios, Wireless Technologies, and Microcirculation.Journal of cardiovascular development and disease · 2026Review
- Noninvasive MRA-derived fractional flow for intracranial stenosis: methodological evaluation and hemodynamic insights.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundEven though current guidelines recommend intracoronary pressure measurement such as fractional flow reserve (FFR) to assess the hemodynamic relevance of angiographically intermediate stenoses, little is known about the incidence of side effects and there is no large-scale data on complications of intracoronary pressure measurements.
methodsThe PubMed database was searched for large multicenter trials and registries of patients undergoing intracoronary pressure measurement. Publications were screened regarding side effects and complications. Data on chest pain, dyspnea, arrhythmia, bronchospasm, hypotension, nausea, and coronary artery injury were collected and analyzed.
resultsA total of 19 studies with 22,768 patients were included. FFR measurement was reported to cause chest pain in 29% (95% CI 2-91%), dyspnea in 20%, hypotension in 0.8% (95% CI 0.3-2.1%), vomiting or nausea in 0.9%, and bronchospasm in 0.2% (95% CI 0.0-0.7%) of patients. Arrhythmia occurred in 3% (95% CI 1-16%), more specifically atrioventricular block in 2% (95% CI 0-14%) and ventricular arrhythmia in 0.1% (95% CI 0.1-0.3%), during intracoronary pressure measurement. The pressure wire was reported to have caused coronary artery dissection in 0.2% (95% CI 0.1-0.5%), coronary artery occlusion in 0.2% (95% CI 0.1-0.3%), and coronary artery perforation in 0.1% of patients. Coronary artery injury required revascularization on rare occasions and was fatal in two patients.
conclusionsTransient side effects due to adenosine administration are common when FFR is measured. While infrequent, coronary artery injury caused by the pressure wire occurs in 0.5% of patients and is a relevant complication of intracoronary pressure measurement.
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Registered trials
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