Evidence map›Paper›PMID 41247469›Full record

ArticleArchives of gynecology and obstetrics2025

Prognostic factors for malignant tumors arising from mature cystic teratomas: a study involving the Kansai Clinical Oncology Group (KCOG-G1305s study).

Fuminori Ito, Mototsugu Shimokawa, Atsushi Sugiura, Yoshio Itani, Atsushi Arakawa, Kayo Inoue, Mamiko Onuki, Tadahiro Shoji, Tomomi Egawa-Takata, Yuji Takei and 9 more

Abstract readMulticenter Study
In one paragraph

Article in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Fuminori ItoDepartment of Obstetrics and Gynecology, Nara Prefecture General Medical Center, 2-1-1 Sanjo Oji, Nara, 630-8122, Japan. f_ito_0624@yahoo.co.jp.ORCID 0000-0002-0437-0979
Mototsugu ShimokawaDepartment of Biostatistics, Yamaguchi University Graduate School of Medicine, 1-1-1, Yoshida, Ube, Yamaguchi, Japan.ORCID 0000-0001-8140-4565
Atsushi SugiuraDepartment of Obstetrics and Gynecology, Musashino Red Cross Hospital, 2-8-1 Kichijoji Minamicho, Musashino-shi, Tokyo, 180-8610, Japan.
Yoshio ItaniDepartment of Palliative Care Center, Yao Municipal Hospital, 1-1-1, Yao, Osaka, 581-0081, Japan.
Atsushi ArakawaDepartment of Obstetrics and Gynecology, Nagoya City University West Medical Center, 2-17-1, Kurokawa, Nishi-ku, Nagoya, Aichi, 451-0054, Japan.
Kayo InoueDepartment of Obstetrics and Gynecology, Konan Medical Center, 1-5-16 Kamoko-ga-hara, Higashi Nada-ku, Kobe-shi, Hyogo, 658-0064, Japan.
Mamiko OnukiDepartment of Obstetrics and Gynecology, Showa University, 2-579-15, Kitakamata, Hachioji-shi, Tokyo, 192-0395, Japan.
Tadahiro ShojiDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 1-1-1, Uchimaru, Morioka-shi, Iwate, 020-8505, Japan.
Tomomi Egawa-TakataDepartment of Obstetrics and Gynecology, Kansai Rosai Hospital, 3-1-69 Inabaso, Amagasaki-shi, Hyogo, 660-8511, Japan.
Yuji TakeiDepartment of Obstetrics and Gynecology, Jichi Medical University, 333-1, Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.
Kazuhiro TakeharaDepartment of Gynecologic Oncology, NHO Shikoku Cancer Center, 4-1-1, Hachiman-cho, Matsuyama, Ehime, 790-0008, Japan.
Takashi MotohashiDepartment of Obstetrics and Gynecology, Tokyo Women's Medical University, 2-2-3 Minato, Shinjuku-ku, Tokyo, 160-8402, Japan.ORCID 0000-0003-3459-7485
Hiroaki NaganoDepartment of Obstetrics and Gynecology, Tokyo Women's Medical University Adachi Medical Center, 2-1-1, Takashimadai, Adachi-ku, Tokyo, 123-0185, Japan.
Toshiaki NakamuraDepartment of Obstetrics and Gynecology, Kagoshima City Hospital, 1-1, Yamashita-cho, Kagoshima, Kagoshima, Japan.
Satoru MunakataDepartment of Pathology, Hakodate Municipal Hospital, 1-1-1, Honcho, Hakodate, Hokkaido, Japan.
Takashi YamadaDepartment of Pathology, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, Osaka, 569-1094, Japan.
Naoto FurukawaDepartment of Obstetrics and Gynecology, Takai Hospital, 461-2 Kurano-sho-cho, Tenri-shi, Nara-ken, Japan.
Tsunekazu KitaDepartment of Obstetrics and Gynecology, Nara Prefecture General Medical Center, 2-1-1 Sanjo Oji, Nara, 630-8122, Japan.
Kimihiko ItoDepartment of Obstetrics and Gynecology, Kansai Rosai Hospital, 3-1-69 Inabaso, Amagasaki-shi, Hyogo, 660-8511, Japan.ORCID 0000-0002-3115-7997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCurrent data regarding prognostic factors for malignant tumors arising from mature cystic teratomas (MT-MCTs) and effective treatments are insufficient. This study aimed to identify risk factors for MT-MCTs of the ovary.

methodsTumor samples diagnosed as MT-MCTs were collected from 13 institutions that participated in the Kansai Clinical Oncology Group. Based on the clinicopathological features and prognoses of the tumors, risk factors for progression and death were statistically assessed using univariable and multivariable analyses.

resultsAmong the 60 tumor samples collected, 56 were diagnosed as MT-MCTs. Four samples were excluded based on the results of a central pathological review. Nine histological types, including squamous cell carcinoma, were diagnosed. Thirty of the 56 included samples were classified as International Federation of Gynecology and Obstetrics (FIGO) stage I, seven were classified as FIGO stage II, 18 were classified as FIGO stage III, and one was classified as FIGO stage IV. The 5-year progression-free survival and overall survival probabilities for stage I disease were significantly higher than those for stages II-IV disease (p < 0.001). In the multivariable analysis, surgery with residual tumor margins was a prognostic factor for progression, and FIGO stages I-IV and the absence of adjuvant therapy were prognostic factors for death.

conclusionSurgery without residual tumor margins and adjuvant therapy may be promising treatments for advanced-stage MT-MCTs.

Indexed as

Ovarian NeoplasmsTeratomaAdultAgedDisease ProgressionFemaleHumansJapanMargins of ExcisionMiddle AgedNeoplasm StagingPrognosisProgression-Free SurvivalRisk FactorsYoung AdultOverall survivalProgression-free survivalSquamous cell carcinoma

Identifiers

PMID41247469
PMCPMC12705796

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