Evidence map›Paper›PMID 41247457›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

An endogenous human peptide derived from α

Stefanie Lietz, Lena-Marie Sokolowski, Alexander Beyschlag, Helena Rosenau, Annika Siewert, Armando A Rodríguez Alfonso, Nico Preising, Ludger Ständker, Sebastian Wiese, Janet Köhler and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stefanie LietzInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, Ulm University Medical Center, 89081, Ulm, Germany.
Lena-Marie SokolowskiInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, Ulm University Medical Center, 89081, Ulm, Germany.
Alexander BeyschlagInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, Ulm University Medical Center, 89081, Ulm, Germany.
Helena RosenauInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, Ulm University Medical Center, 89081, Ulm, Germany.
Annika SiewertInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, Ulm University Medical Center, 89081, Ulm, Germany.
Armando A Rodríguez AlfonsoCore Facility Functional Peptidomics, Ulm University Medical Center, 89081, Ulm, Germany.
Nico PreisingCore Facility Functional Peptidomics, Ulm University Medical Center, 89081, Ulm, Germany.
Ludger StändkerCore Facility Functional Peptidomics, Ulm University Medical Center, 89081, Ulm, Germany.
Sebastian WieseCore Unit Mass Spectrometry and Proteomics, Ulm University Medical Center, 89081, Ulm, Germany.
Janet KöhlerInstitute of Biochemistry and Molecular Biology, Ulm University, 89081, Ulm, Germany.
Gilbert WeidingerInstitute of Biochemistry and Molecular Biology, Ulm University, 89081, Ulm, Germany.
Jan MünchInstitute of Molecular Virology, Ulm University Medical Center, 89081, Ulm, Germany.
Arto T PulliainenInstitute of Biomedicine, University of Turku, 20520, Turku, Finland.
Katharina ErnstInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, Ulm University Medical Center, 89081, Ulm, Germany.
Holger BarthInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, Ulm University Medical Center, 89081, Ulm, Germany. holger.barth@uni-ulm.de.

Funding

Deutsche Forschungsgemeinschaft 316249678-SFB1279DFG 316249678-SFB1279
6 · The paper itself

Abstract

Pertussis, also known as whooping cough, is a highly infectious respiratory disease caused by the bacterium Bordetella pertussis. The bacterial virulence factor, pertussis toxin (PT), is associated with the manifestation of the characteristic symptoms of pertussis and the severe form of this disease. Increasing case numbers and the lack of treatment options highlight the need to develop novel pharmacological strategies, e.g., the generation of specific PT inhibitors. Recently, we identified the endogenous human protein α

Indexed as

alpha 1-AntitrypsinBordetella pertussisPeptide FragmentsPeptidesPertussis ToxinAnimalsHumansZebrafishalpha 1-AntitrypsinPeptide FragmentsPeptidesPertussis ToxinBordetella pertussisEndogenous peptidesEndogenous proteinsPertussis toxinToxin inhibitorα1-antitrypsin

Identifiers

PMID41247457
PMCPMC13046643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.