Evidence map›Paper›PMID 41247404›Full record

ArticleJournal of bone and mineral metabolism2026

Changes in bone metabolism dynamics in response to mechanical stress under pulmonary emphysema.

Daisuke Arakawa, Manabu Tsukamoto, Ke-Yong Wang, Takayuki Nabeshima, Yosuke Mano, Yoshiaki Yamanaka, Hitoshi Suzuki, Makoto Kawasaki, Eiichiro Nakamura, Kagaku Azuma and 2 more

Abstract read
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In one paragraph

Article in Journal of bone and mineral metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daisuke ArakawaDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Manabu TsukamotoDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan. m-tsuka@med.uoeh-u.ac.jp.ORCID http://orcid.org/0000-0003-4577-5072
Ke-Yong WangShared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Takayuki NabeshimaDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Yosuke ManoDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Yoshiaki YamanakaDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Hitoshi SuzukiDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Makoto KawasakiDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Eiichiro NakamuraDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Kagaku AzumaDepartment of Anatomy, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Kazuhiro YateraDepartment of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Akinori SakaiDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.

Funding

Japan Society for the Promotion of Science London 20K09446Japan Society for the Promotion of Science London 23K15702
6 · The paper itself

Abstract

introductionThere are many risk factors for fractures in chronic obstructive pulmonary disease patients, and investigating the effects of any particular factor on bones is extremely difficult. We hypothesized that the presence of pulmonary emphysema would delay the recovery of bone mass by reloading after unloading, and our study aimed to assess changes in bone metabolism dynamics in response to mechanical stress under pulmonary emphysema in model mice. MATERIALS AND

methodsWe used C57BL/6J mice, with or without emphysema, via intratracheal administration of elastase or vehicle. Half of these mice underwent 1 week of hindlimb unloading followed by reloading, with bone assessed by μCT and histomorphometry.

resultsMice without emphysema exhibited transient bone loss, with bone mass fully recovering by week 3 after unloading, driven by a robust rebound in bone formation. Conversely, mice with emphysema showed a delay in the response of bone metabolism dynamics to mechanical stress; bone loss due to unloading were delayed by week 3 after unloading and bone recovery due to reloading by week 6.

conclusionsSlow changes in bone metabolism dynamics were observed during both unloading and reloading in mice with elastase-induced emphysema. The mechanism underlying these phenomena is unclear and requires further investigation.

Indexed as

Bone and BonesPulmonary EmphysemaStress, MechanicalAnimalsHindlimb SuspensionMaleMiceMice, Inbred C57BLPancreatic ElastaseX-Ray MicrotomographyPancreatic ElastaseBone histomorphometryCOPDDisuse osteoporosisMechanical stressSecondary osteoporosis

Identifiers

PMID41247404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.