Evidence map›Paper›PMID 41247385›Full record

Trial reportEuropean journal of pediatrics2025

Non-invasive open lung strategy in delivery room: randomized controlled trial (OpenCPAP-DR).

Nuray Duman, Mehtap Durukan Tosun, Funda Tuzun, Tugba Egeli, Ahmet Yagmur Bas, Meryem Merve Pamukcu, Burak Deliloglu, Can Akyildiz, Coskun Armagan, Pembe Keskinoglu and 2 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05031650 (Can Open Lung Strategy During Non-Invasive Respiratory Support of Very Premature Infants in the Delivery Room Reduce Non-Invasive Ventilation Failure Compared With Standard Approach? A Randomised Controlled Multicentric Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05031650 nacompletednot on this map

Can Open Lung Strategy During Non-Invasive Respiratory Support of Very Premature Infants in the Delivery Room Reduce Non-Invasive Ventilation Failure Compared With Standard Approach? A Randomised Controlled Multicentric Trial

TypeinterventionalSponsorDokuz Eylul UniversityRan2019 to 2023Enrolled145ConditionsRespiratory Distress Syndrome in Premature Infant, Non-invasive Ventilation, Lung InjuryArmsopenCPAP, standardCPAP
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Initial CPAP of 5 versus 8 cmHEuropean journal of pediatrics · 2026
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nuray DumanDepartment of Neonatology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.ORCID http://orcid.org/0000-0003-0545-2914
Mehtap Durukan TosunDepartment of Neonatology, Etlik Zubeyde Hanım Women's Health Training and Research Hospital, University of Health Sciences, Ankara, Turkey.ORCID http://orcid.org/0000-0002-4041-2777
Funda TuzunDepartment of Neonatology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.ORCID http://orcid.org/0000-0001-5348-1168
Tugba EgeliDepartment of Neonatology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.ORCID http://orcid.org/0000-0003-1014-4852
Ahmet Yagmur BasDepartment of Neonatology, Ankara Yıldırım Beyazıt University, Ankara, Turkey.ORCID http://orcid.org/0000-0002-1329-2167
Meryem Merve PamukcuDepartment of Neonatology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.ORCID http://orcid.org/0000-0003-1622-4087
Burak DelilogluDepartment of Neonatology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.ORCID http://orcid.org/0000-0002-1914-6099
Can AkyildizDepartment of Neonatology, School of Medicine, Dokuz Eylul University, Izmir, Turkey. can.akyildiz@deu.edu.tr.ORCID http://orcid.org/0000-0002-7087-7006
Coskun ArmaganDepartment of Neonatology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.ORCID http://orcid.org/0000-0001-9716-130X
Pembe KeskinogluDepartment of Biostatistics, School of Medicine, Dokuz Eylul University, Izmir, Turkey.ORCID http://orcid.org/0000-0002-3459-1828
Nihal DemirelDepartment of Neonatology, Ankara Yıldırım Beyazıt University, Ankara, Turkey.ORCID http://orcid.org/0000-0003-2044-2212
Hasan OzkanDepartment of Neonatology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.ORCID http://orcid.org/0000-0003-2542-7441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aimed to compare the effects of individualized nasal continuous positive airway pressure (nCPAP) therapy using different positive end-expiratory pressure (PEEP) levels on heart rate, SpO

conclusionThis randomized clinical trial evaluated the effects of different PEEP levels in the delivery room management of very preterm infants. Initiating CPAP support at 6 cmH

trial registrationOpen lung strategy during non-invasive respiratory support of very preterm infants in the delivery room (OpenCPAP-DR), NCT05031650, 26 August 2021 https://clinicaltrials.gov/study/NCT05031650?term=Nuray%20duman&rank=1 , deidentified individual participant data will not be made available. WHAT IS KNOWN: • There is no specific evidence-based pressure level for early nCPAP recommended in the delivery room for very preterm infants. WHAT IS NEW: • When stabilizing very preterm infants in the delivery room, it has been found prudent to increase pressure rather than increase oxygen first when using nCPAP if the target oxygen saturation is not reached.

Indexed as

Continuous Positive Airway PressureRespiratory Distress Syndrome, NewbornDelivery RoomsFemaleHeart RateHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMaleOxygen SaturationPositive-Pressure RespirationPulmonary SurfactantsPulmonary SurfactantsDelivery roomOpen lung strategyPositive end-expiratory pressureRDSVery preterm infants

Identifiers

PMID41247385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.