ArticleThe journal of trauma and acute care surgery2026
Trauma-induced alterations in bone marrow exosome microRNA profiles.
Article in The journal of trauma and acute care surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundSevere trauma disrupts bone marrow function, triggering physiological changes that impair hematopoiesis, immune cell production, and the bone marrow microenvironment. Bone marrow-derived exosomes play a critical role in intercellular communication, but their contribution to the cellular response to injury remains poorly understood. This study investigates bone marrow exosome microRNA (miRNA) expression in rodents subjected to polytrauma (PT) with and without chronic stress exposure, a model simulating chronic critical illness following injury.
methodsBone marrow was collected from rats (n = 12/group) subjected to PT, including lung contusion, hemorrhagic shock, cecal ligation, and pseudofracture. A second group underwent PT with daily restraint stress to model chronic critical illness. Bone marrow-derived exosomes were isolated 7 days postinjury, and miRNA expression was quantified using ROSALIND Bioinformatics Software (Healthcare Technology Systems, San Diego, CA) with significance defined as p < 0.05.
resultsBoth PT and PT with daily restraint stress significantly altered the bone marrow-derived exosome miRNA cargo. Following PT, several miRNAs associated with inflammation, apoptosis, and progenitor cell regulation (miR-216b, miR-1929, miR-3472) were upregulated, and key miRNAs involved in hematopoietic stem/progenitor growth maintenance (let-7c, miR-21, miR-126b-3p) were significantly downregulated. The addition of chronic stress after PT further amplified these changes, with upregulation of pro-inflammatory and immune-regulatory miRNAs (miR-146b, miR-1940, miR-875-3p) and further suppression of miRNAs critical for erythropoiesis and regeneration (miR-144, miR-125b-5p, let-7a).
conclusionChronic critical illness following severe trauma alters bone marrow exosome miRNA profiles, modulating gene regulatory mechanisms involved in injury response, inflammation, and recovery. These patterns suggest that chronic stress exacerbates trauma-induced bone marrow dysfunction by disrupting hematopoietic stem/progenitor growth maintenance, lineage specification, and tissue repair signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.