ArticleNano letters2025
Engineering Two-Dimensional Nanobody-Origami Architectures for Enhanced Antiviral Activity.
Article in Nano letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Advances in DNA nanostructures for pathogenic microorganisms.Materials today. Bio · 2026Review
- DNA Origami-Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity.Advanced materials (Deerfield Beach, Fla.) · 2026Article
Corrections and comments
- Update of
Authors and funding
10 authors.
Funding
Abstract
The nanoscale organization of binding ligands offers a powerful strategy to combat viral infections. Herein, we report a programmable 2D DNA origami platform that enables nanoscale control of multivalent nanobody (Nb) spatial patterns for a broad-spectrum antiviral application. By site-selective Nb-DNA conjugation and spatial positioning on 2D origami, we synthesized origami-Nb nanoarchitectures with Nb patterns rationally designed to approximately match the geometric presentation of viral surface proteins. We demonstrate that Nb configurations greatly enhanced viral binding affinity and neutralization potency. For SARS-CoV-2, a triangular Nb pattern matching that of the spike proteins achieved an IC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.