Evidence map›Paper›PMID 41247044›Full record

ArticlemBio2025

Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation.

Shaobo Wang, Wanyu Li, Jing Wen, Lingling Wang, Shashi Kant Tiwari, William Bray, Lujing Wu, Na Li, Hui Hui, Alex E Clark and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Shared host genetic landscape of respiratory viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Shaobo Wang *Department of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.
Wanyu Li *Department of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.
Jing Wen *Department of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.ORCID 0009-0001-4627-4598
Lingling WangDepartment of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.
Shashi Kant TiwariDepartment of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.
William BrayDepartment of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.
Lujing WuDepartment of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.
Na LiDepartment of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.
Hui HuiDepartment of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.
Alex E ClarkDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Qiong ZhangDepartment of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.
Lingzhi ZhangDepartment of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.
Aaron F CarlinDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-1669-8066
Tariq M RanaDepartment of Cellular and Molecular Medicine, Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, USA.ORCID 0000-0001-9558-5766

Funding

Modeling HIV/AIDS Associated Neurological Disorders with Human Pluripotent CellsDP1DA039562 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, TARIQ M · 2015 to 2020
$3.9M
Identification and Regulation of RNA Modification by HIV infection and MethamphetamineR01DA046171 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, TARIQ M · 2018 to 2022
$3.1M
Deconvolution of pro- and anti-viral responses to Dengue virus and Zika Virus infectionsK08AI130381 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARLIN, AARON F. · 2019 to 2023
$1.0M
Role of PCIF1 in Regulating Host-HIV interactionsR56AI187411 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, TARIQ M · 2024 to 2024
$503k
Regulation of HIV-1 Replication by Cellular IncRNAsR21AI125103 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, TARIQ M · 2016 to 2017
$426k
Burroughs Wellcome Fund USANIAID NIH HHS K08 AI130381NIAID NIH HHS R21 AI125103NIAID NIH HHS R56 AI187411NIDA NIH HHS DP1 DA039562NIDA NIH HHS R01 DA046171
6 · The paper itself

Abstract

Viral infection induces production of type I interferons and expression of interferon-stimulated genes (ISGs) that play key roles in inhibiting viral infection. Here, we show that the ISG guanylate-binding protein 5 (GBP5) inhibits N-linked glycosylation of key proteins in multiple viruses, including SARS-CoV-2 spike protein. GBP5 binds to accessory subunits of the host oligosaccharyltransferase (OST) complex and blocks its interaction with the spike protein, which results in misfolding and retention of the spike protein in the endoplasmic reticulum likely due to decreased

Indexed as

GlycoproteinsGTP-Binding ProteinsHexosyltransferasesMembrane ProteinsSARS-CoV-2Virus ReplicationAnimalsGlycosylationHEK293 CellsHIV-1HumansProtein BindingSpike Glycoprotein, Coronavirusdolichyl-diphosphooligosaccharide - protein glycotransferaseGlycoproteinsGTP-Binding ProteinsHexosyltransferasesMembrane ProteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2GBP5human immunodeficiency virusN-linked glycosylationoligosaccharyltransferase (OST) complexSARS-CoV-2spike protein

Identifiers

PMID41247044
PMCPMC12691697

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.