Evidence map›Paper›PMID 41247037›Full record

ArticleEnvironmental science & technology2025

Detection of Metal-Containing Particles in FDA-Authorized and New Disposable Electronic Cigarette Aerosols.

Sarah-Marie Alam El Din, Sampada Iyengar, Angela D Aherrera, C Derrick Quarles, Jana Mihalic, Joseph Bressler, Ana M Rule

Abstract read
In one paragraph

Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah-Marie Alam El DinDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States.ORCID 0000-0003-3174-6625
Sampada IyengarDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States.
Angela D AherreraDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States.
C Derrick QuarlesElemental Scientific, Inc., Omaha, Nebraska 68122, United States.
Jana MihalicDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States.
Joseph BresslerDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States.
Ana M RuleDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States.ORCID 0000-0003-2328-0749

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
The Exposure to Metals from E-Cigarettes (EMIT) StudyR01ES030025 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI RULE, ANA MARIA · 2018 to 2020
$1.5M
Respiratory Effects, Metal and Aldehyde exposure from e-cigarette use in young adults (REMA)R00ES034507 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Angela Aherrera · 2024 to 2026
$747k
ICP-QQQS10OD030355 · OD · JOHNS HOPKINS UNIVERSITY · PI RULE, ANA MARIA · 2021 to 2021
$350k
Respiratory Effects, Metal and Aldehyde exposure from e-cigarette use in young adults (REMA)K99ES034507 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI AHERRERA, ANGELA · 2022 to 2023
$319k
NIEHS NIH HHS K99 ES034507NIEHS NIH HHS R00 ES034507NIEHS NIH HHS R01 ES030025NIEHS NIH HHS T32 ES007141NIH HHS S10 OD030355
6 · The paper itself

Abstract

Use of electronic cigarettes (e-cigs) among youth raises concerns about nicotine addiction and health risks, highlighting the urgency of understanding e-cig aerosol composition. While metals in e-cig aerosols are well-documented, the presence of metals as particles versus ions in newer disposable devices remains unclear. We examined metal particles in aerosols from disposable e-cigs and FDA-authorized devices. E-cigs analyzed included Vuse Alto (FDA-authorized), EB Create, and Orion Bar. Aerosol condensate was analyzed for arsenic (As), cadmium (Cd), chromium (Cr), iron (Fe), nickel (Ni), lead (Pb), and zinc (Zn) by using single-particle inductively coupled plasma-mass spectrometry. The bulk metal content, particle size, mass, and 1 month stability were also assessed. The particle size was determined based on the assumption that particles contained the detected single metal alone and not the oxide. All aerosols analyzed contained metals, with Cr, Ni, Fe, Pb, and Zn detected as particles. The FDA-authorized Vuse Alto Golden Tobacco device consistently exhibited the highest particle count for all metals, except Cr. EB Create aerosols had the highest amount of Cr particles. Particle sizes ranged from 14.21 to 281.3 nm. The widespread presence of metal particles in e-cig aerosols raises public health concerns and underscores the need for research to inform regulatory standards.

Indexed as

Electronic Nicotine Delivery SystemsMetalsAerosolsParticle SizeUnited StatesUnited States Food and Drug AdministrationAerosolsMetalselectronic cigarettesmetal particlesmetalssingle-particle ICP−MS

Identifiers

PMID41247037
PMCPMC12969321

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.