ArticleThe American journal of gastroenterology2026
Sequence Analysis Identifies Clusters of Antibiotic Use After the First Episode of Pouchitis in a Population-Based Study That May Represent High-Risk Phenotypes.
Article in The American journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionEvaluate antibiotic patterns in the 12 months after an initial episode of pouchitis and associated factors.
methodsIn a population-based cohort, we identified the first episode of pouchitis (within 12 months of ileal pouch-anal anastomosis surgery) and used sequence analysis to identify antibiotic treatment patterns in the subsequent 12 months.
resultsAmong 662 patients, we identified 4 clusters of antibiotic prescribing patterns, corresponding to patterns of intermittent and chronic pouchitis. Patients with chronic antibiotic-dependent pouchitis received antibiotics in most intervals after an initial episode of pouchitis. DISCUSSION: High-risk phenotypes after an initial episode of pouchitis suggest the need to evaluate the role of secondary prevention strategies.
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