Evidence map›Paper›PMID 41246822›Full record

ArticleJournal of food science2025

Bioactive Compounds Extraction From Moringa oleifera Leaves: A Comparative Study of Vacuum-Assisted and Bed-Stirred Extractions.

Olívia J S Gomes, Anabela Leitão, Hermínio C de Sousa, Licínio M Gando-Ferreira, Mara E M Braga

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Olívia J S GomesDepartment of Chemical Engineering, Faculty of Sciences and Technology, University of Coimbra, CERES, Coimbra, Portugal.
Anabela LeitãoLESRA - Laboratory of Separation, Reaction and Environmental Engineering, Faculty of Engineering, Agostinho Neto University, Luanda, Angola.
Hermínio C de SousaDepartment of Chemical Engineering, Faculty of Sciences and Technology, University of Coimbra, CERES, Coimbra, Portugal.
Licínio M Gando-FerreiraDepartment of Chemical Engineering, Faculty of Sciences and Technology, University of Coimbra, CERES, Coimbra, Portugal.
Mara E M BragaDepartment of Chemical Engineering, Faculty of Sciences and Technology, University of Coimbra, CERES, Coimbra, Portugal.ORCID https://orcid.org/0000-0003-4142-4021

Funding

Fundação para a Ciência e a Tecnologia
6 · The paper itself

Abstract

Moringa oleifera leaves are a rich source of bioactive compounds with antioxidant and anti-inflammatory properties. However, the efficient extraction of these compounds depends on optimized process conditions and suitable extraction techniques that ensure high yield with the compound's stability. Conventional extraction methods often expose compounds to heat and an oxidative environment, which can degrade sensitive molecules. To address this, this study evaluated the extraction efficiency of these bioactive compounds using a hydroethanolic solvent through vacuum-assisted extraction (VAE) method. For comparison purposes, the bed-stirred extraction (BSE) was also performed. A design of experiments was applied to optimize the process, identifying the solid-solvent ratio (1:150, g/mL) as a key factor for both extraction methods, with similar optimal ethanol concentrations of around 80% for BSE and VAE methods. VAE significantly increased the recovery of total phenolic and flavonoid compounds by 37% and 48%, respectively, and four times the vitamin content compared to BSE. This is due to the enhanced penetration of solvents and the protection of bioactive compounds from oxidation under vacuum conditions. VAE extracts exhibited stronger free radical scavenging in DPPH and ABTS assays (23 ± 1 and 28 ± 1 µg/mL, respectively), with IC

Indexed as

Chemical FractionationMoringa oleiferaPlant ExtractsPlant LeavesAnti-Inflammatory AgentsAntioxidantsFlavonoidsPhenolsSolventsVacuumAnti-Inflammatory AgentsAntioxidantsFlavonoidsPhenolsPlant ExtractsSolventsanti‐inflammatoryantioxidant activityMoringa oleiferastirred water bath extractionvacuum‐assisted extraction

Identifiers

PMID41246822
PMCPMC12621288

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.