ArticleJournal of the American Heart Association2025
Circulating Markers of Inflammation and Endothelial Dysfunction Associated With Increased Progression of Internal Carotid Intima-Media Thickness in the Population-Based Framingham Heart Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Molecular Basis of Adipose-Cardiac Crosstalk in Cardiovascular Diseases: From Mechanisms to Therapeutic Opportunities.Biomolecules · 2026Review
- Plasma FGF21 is associated with intracranial atherosclerotic stenosis in patients with type 2 diabetes mellitus.Frontiers in neurology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCirculating markers of inflammation may be associated with carotid artery intima-media thickness (CIMT), a marker of subclinical atherosclerosis associated with cardiovascular and cerebrovascular disease, although the exact relationship between these circulating markers of inflammation and progression of CIMT is unclear. We hypothesize that markers of circulating inflammation and endothelial dysfunction are associated with progression of CIMT in the FHS (Framingham Heart Study) cohort.
methodsMultivariable linear regression was used to assess the association between specific circulating markers of inflammation with cross-sectional internal CIMT (ICIMT) measurement and ICIMT progression defined as rate of change of intima-media thickness (mm/y) in the internal carotid artery. Our primary analyses adjusted for age, sex, hypertension, diabetes,
resultsWe studied 2264 participants (mean age 57.2 years, 54% women). In our primary multivariable adjusted analysis, we observed that participants with higher baseline C-reactive protein (β=0.057 [95% CI, 0.012-0.102];
conclusionsSpecific markers of inflammation and endothelial dysfunction were associated with increased ICIMT and carotid atherosclerosis progression.
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