ArticleJournal of the American Heart Association2025
Sex Differences in Atherosclerotic Coronary Artery Disease Patterns.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Peak filling rate assessed by myocardial perfusion imaging predicts adverse outcomes in women with chronic coronary syndromes.Quantitative imaging in medicine and surgery · 2026Article
- Sex-specific assumptions underlie cardiovascular digital twin technologies: A narrative review.PLOS digital health · 2026Review
- Sex differences in MASLD-related atherosclerosis: plaque phenotype, vascular dysfunction, and cardiovascular outcomes.Biology of sex differences · 2026Review
- Determinants of left ventricular hypertrophy in a cohort attending a medical clinic: A comparative analysis stratified by sex.PLOS global public health · 2026Article
Corrections and comments
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Authors and funding
44 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSex differences in coronary artery disease (CAD) have been increasingly recognized, as women present with distinct clinical characteristics and outcomes compared with men. This study investigated the impact of sex on pathophysiological CAD patterns (focal versus diffuse) in stable patients undergoing percutaneous coronary interventions (PCI).
methodsWe conducted a subanalysis of the PPG Global (Pullback Pressure Gradient Global Registry) study, a multicenter, prospective trial including 993 patients (236 [23.8%] women and 757 [76.2%] men) with hemodynamically significant CAD, defined as fractional flow reserve ≤0.80. The pullback pressure gradient metric categorized CAD patterns as focal or diffuse. Patient-reported outcomes were collected using the 7-item Seattle Angina Questionnaire. Optimal revascularization was defined as post-PCI fractional flow reserve ≥0.88.
resultsWomen were significantly older than men, with a mean age of 69.8±10.3 years compared with 67.0±10.1 years (
conclusionsThis study reveals clinically significant differences in CAD patterns between sexes, with women demonstrating a higher burden of angina, more focal disease distribution, and better physiological results after PCI.
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Registered trials
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