ArticleCureus2025
A Comparative Prospective Assessment of Preoperative 5% Dextrose and Normal Saline Loading on Outcomes Following Laparoscopic Cholecystectomy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The Effect of Intravenous Dextrose Administration on Postoperative Nausea and Vomiting: Systematic Review and Meta-Analysis with Trial Sequential Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLaparoscopic cholecystectomy is still accompanied by postoperative pain, nausea, and vomiting, and the use of intravenous dextrose, though suggested to decrease the mentioned complications, has not been confirmed yet. The purpose of the study was to evaluate the effects of intravenous preoperative 5% dextrose and normal saline on postoperative pain, nausea, vomiting, and discharge fitness in patients undergoing elective laparoscopic cholecystectomy.
methods100 patients undergoing laparoscopic cholecystectomy were involved in a comparative prospective study. The subjects were divided into two categories, i.e., Group A (dextrose, n=50) and Group B (normal saline, n=50). Demographic and clinical factors, such as age, gender, American Society of Anesthesiologists (ASA) status, and BMI, were taken. Demographic factors were further stratified into groups of postoperative outcomes of abdominal pain, nausea, vomiting, and fitness at discharge. The p-value was set at p<0.05.
resultsThe average age was 44.3 ± 9 years, and the females constituted 75 % of the participants in the study. There were no differences in age, sex, ASA status, or BMI (p>0.05). The abdominal pain during the postoperative period (20% vs. 52% p=0.001) and nausea (14% vs. 36% p=0.011) were significantly increased in the saline group than the dextrose group. There was no statistically significant difference in vomiting (20% vs. 30%, p=0.248) or discharge fitness (58% vs. 48%, p=0.316). Subgroup analyses revealed significant correlations of both pain and nausea with female sex, status of ASA I, and BMI.
conclusionDextrose intravenous preoperative loading was found to be better than normal saline in reducing postoperative abdominal pain and nausea, which indicated that intravenous dextrose preoperative loading was an inexpensive approach to relieve postoperative pain and nausea after laparoscopic cholecystectomy.
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