ReviewCureus2025
3D-Printed Patient-Specific Instrumentation Versus Conventional Techniques in Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07628010 (Modern Methods of Treatment and Diagnosis in Patients With Musculoskeletal Injuries and Diseases), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modern Methods of Treatment and Diagnosis in Patients With Musculoskeletal Injuries and Diseases
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
3D-printed patient-specific instrumentation (PSI) in total knee arthroplasty (TKA) has been proposed to improve surgical precision and outcomes compared to conventional instrumentation (CI), but its clinical benefits remain uncertain. We conducted a systematic review and meta-analysis of 14 comparative studies, including 2,704 TKA procedures, evaluating surgical time, intraoperative blood loss, alignment accuracy, and malalignment rates. Databases searched included PubMed, Embase, Scopus, Web of Science, and Cochrane CENTRAL. Random-effects meta-analysis demonstrated that PSI significantly reduced hip-knee-ankle alignment outliers (OR = 0.30, p < 0.00001), improved overall alignment accuracy (standardized mean difference (SMD) = -0.27, p = 0.02), and decreased intraoperative blood loss (SMD = -1.05, p = 0.009), while no significant difference was observed in surgical time (SMD = -0.78, p = 0.17), despite high heterogeneity. Complication rates were similar between groups. These findings indicate that 3D-printed PSI enhances alignment precision and reduces blood loss in TKA without increasing perioperative risk, highlighting its potential utility in complex cases or high-volume surgical settings. However, these results should be interpreted with caution given the predominance of observational studies and generally short follow-up durations among the included literature. Further high-quality trials are warranted to clarify its long-term clinical, functional, and economic impact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.