ArticleIJTLD open2025
Depression in adolescents on treatment for rifampicin-susceptible TB in Lima, Peru.
Article in IJTLD open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundAt least 1 million adolescents develop TB disease annually. Adolescents are also at risk for depression due to TB, but this is poorly understood.
methodsThis prospective cohort study aimed to identify the frequency and risk factors for depression amongst adolescents with rifampicin-susceptible TB in Lima, Peru. During weeks 3-5 of treatment, participants completed a survey that included socio-demographic characteristics, symptoms, treatment side effects, and the Patient Health Questionnaire-9 depression scale. Those with depression received psychological evaluation and were referred for treatment, with treatment intensity corresponding to depression severity. Applying k-means cluster analysis, we grouped participants by socio-demographic characteristics. We used generalised linear mixed-effects regression to model the relationship between cluster, symptoms and side effects, and depression.
resultsOf 249 participants, 98 (39%), 62 (25%), and 33 (13%) had mild, moderate, and severe depression, respectively. We identified three clusters; Cluster 1 - adolescents with lower social support and more prior trauma - had the highest frequency of depression. Across all clusters, symptoms and side effects correlated with depression.
conclusionGiven their high frequency of depression, adolescents on TB treatment - particularly those with trauma history, weak social support, or numerous symptoms and side effects - should be routinely screened for depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.