ArticleOpen veterinary journal2025
Histopathological and ultrastructural evaluations of giant African snail (
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Wound healing is a complex biological process that involves inflammation, cellular proliferation, and tissue remodeling. Efficient and prompt wound repair is critical for infection prevention and tissue integrity restoration. Snail mucin contains glycosaminoglycans, proteoglycans, and growth factors that promote fibroblast migration and extracellular matrix formation and reduce inflammatory reactions. Alginate hydrogel, a biocompatible polysaccharide, creates an ideal wet microenvironment, promotes hemostasis, and aids in cellular infiltration and growth. Aim: This study aimed to investigate the effects of snail mucin 96%, alginate hydrogel, and their combination on cutaneous wound healing in a rat model. Methods: Sixty adult rats were randomly divided into five groups ( Results: The snail mucin 96% and Al-Mu 1% groups showed considerably faster wound closure, better histological characteristics, and full healing by day 21. The average percentage of wound contraction was greater than that in the other groups (100%). Healing in the 2% alginate hydrogel and 25% zinc oxide-treated 25% groups was comparable but not as effective as that in the snail mucin-treated groups. The alginate hydrogel group had an average wound contraction rate of 98.78% ± 0.87%, while the zinc oxide-treated group had a rate of 95.38% ± 0.62. The no-treatment group had the lowest healing rate (71.58% ± 9.49%). Conclusion: Snail mucin, either alone or combined with alginate hydrogel, considerably improves wound healing, resulting in full closure and better tissue regeneration by day 21. The mucin-treated groups outperformed the alginate hydrogel and zinc oxide-treated groups, demonstrating the powerful healing effects of snail mucin. These findings show that snail mucin-based therapeutics could be a potential approach to accelerate wound healing and increase tissue restoration.
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