ArticleOpen veterinary journal2025
Silico study: Hepatoprotective effects of capsaicin on the liver of aflatoxin B1-intoxicated mice (
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mycotoxins are secondary metabolites produced by fungi that cause serious diseases and death. Among the mycotoxins, aflatoxins stand out for their significant toxic impact, especially Aflatoxin B1 (AFB1) produced by Aspergillus species. Capsaicin, known for its pungent taste, is also highlighted in this study for its potential health benefits, which have been shown to have beneficial effects on the cardiovascular system, metabolism, analgesia, and management of disorders. Aim: This study aimed to determine the Methods: Molecular docking is a bioinformatics technique that combines biological knowledge with databases (big data) to ascertain the pattern, affinity, and possible activity of chemical compounds interacting with target proteins. When the Gibbs free energy (ΔG) changes, protein-ligand interaction occurs. Results: The findings demonstrated that molecular docking, protein-ligand interactions, homology modeling, target protein prediction, protein interaction analysis, and molecular visualization Conclusion: Capsaicin can synergistically inhibit regulatory cells through the AKT 1 and MAPK 1 signaling pathways, potentiating the hepatotoxicity action protective effect of capsaicin against AFB-1 intoxication. Therefore, capsaicin is a potential candidate for herbal medicine as a hepatoprotective agent.
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