Evidence map›Paper›PMID 41246389›Full record

ArticleOpen veterinary journal2025

Topical anti-inflammatory potential of ethanol extract of

Nuzul Asmilia, Amalia Sutriana, Henni Vanda, Frengki, Mazayya Qanita Manan, Dwi Salsha Reyno, Muhammad Rifqi Al Ikhzan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nuzul AsmiliaDepartment of Clinic Veterinary, Faculty of Veterinary Medicine, Universitas of Syiah Kuala, Banda Aceh, Indonesia.
Amalia SutrianaDepartment of Pharmacology Veterinary, Faculty of Veterinary Medicine, Universitas of Syiah Kuala, Banda Aceh, Indonesia.
Henni VandaDepartment of Pharmacology Veterinary, Faculty of Veterinary Medicine, Universitas of Syiah Kuala, Banda Aceh, Indonesia.
FrengkiDepartment of Pharmacology Veterinary, Faculty of Veterinary Medicine, Universitas of Syiah Kuala, Banda Aceh, Indonesia.
Mazayya Qanita MananDepartment of Clinic Veterinary, Faculty of Veterinary Medicine, Universitas of Syiah Kuala, Banda Aceh, Indonesia.
Dwi Salsha ReynoDepartment of Clinic Veterinary, Faculty of Veterinary Medicine, Universitas of Syiah Kuala, Banda Aceh, Indonesia.
Muhammad Rifqi Al IkhzanDepartment of Pharmacology Veterinary, Faculty of Veterinary Medicine, Universitas of Syiah Kuala, Banda Aceh, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inflammation is a protective mechanism by which the body neutralizes and eradicates harmful agents at the site of injury and conditions tissue repair. Malacca plants contain active metabolites that are believed to be able to cure inflammation. Aim: This study aims to test the formula of ethanol extract cream of Malacca leaves 10%, 15%, and 20% with a negative control group (without treatment) and a positive control group (treated with betamethasone cream) and its anti-inflammatory activity through observation of edema of the feet of male mice induced by carrageenan. Methods: The physical stability of the cream formula was evaluated every week for 3 weeks at room temperature storage (±29°C) by observing organoleptic, pH, viscosity, adhesiveness, and spreadability. Furthermore, an Results: The results of the study showed the most significant decrease in edema volume using 10% (F1) Malacca cream. Differential leukocyte counts showed that the percentage of eosinophils in group K1 was the highest and significantly different ( Conclusion: Ethanol extract of Malacca cream (

Indexed as

Anti-Inflammatory AgentsEdemaInflammationPhyllanthusPlant ExtractsAdministration, TopicalAnimalsCarrageenanDisease Models, AnimalEthanolMaleMicePlant LeavesAnti-Inflammatory AgentsCarrageenanEthanolPlant ExtractsInflammationLeukocyte differentialMalacca leaf ethanol extractPhyllanthus emblicaPlethysmometer

Identifiers

PMID41246389
PMCPMC12613214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.