Evidence map›Paper›PMID 41246354›Full record

ArticleFrontiers in immunology2025

Early responses of primary human and bovine monocytes, monocytic THP-1 cells and THP-1 cell-derived macrophages to vital

Dominik Hanke, Zahady D Velásquez, Kathrin Büttner, Andreas Krueger, Ralf Ross, Andreas Hecker, Sybille Mazurek, Veronika Grau, Anja Taubert, Carlos Hermosilla and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dominik HankeInstitute of Veterinary Physiology and Biochemistry, Justus Liebig University Giessen, Giessen, Germany.
Zahady D VelásquezInstitute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.
Kathrin BüttnerUnit for Biomathematics and Data Processing, Justus Liebig University Giessen, Giessen, Germany.
Andreas KruegerInstitute of Molecular Immunology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.
Ralf RossInstitute of Molecular Immunology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.
Andreas HeckerLaboratory of Experimental Surgery, Department of General and Thoracic Surgery, German Center for Lung Research (DZL), Cardiopulmonary Institute (CPI), Justus Liebig University Giessen, Giessen, Germany.
Sybille MazurekInstitute of Veterinary Physiology and Biochemistry, Justus Liebig University Giessen, Giessen, Germany.
Veronika GrauLaboratory of Experimental Surgery, Department of General and Thoracic Surgery, German Center for Lung Research (DZL), Cardiopulmonary Institute (CPI), Justus Liebig University Giessen, Giessen, Germany.
Anja TaubertInstitute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.
Carlos HermosillaInstitute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.
Katrin Richter *Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, German Center for Lung Research (DZL), Cardiopulmonary Institute (CPI), Justus Liebig University Giessen, Giessen, Germany.
Iván Conejeros *Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Different innate immune cell types are known to release extracellular traps (ETs) in response to invasive pathogens, including parasites. These ETs function to trap, immobilize, and eventually kill pathogens. In line with this, monocytes and macrophages have been shown to release ETs, known as monocyte/macrophage extracellular traps (METs). Methods: Primary human and bovine monocytes, monocytic THP-1 cells, and THP-1 cell-derived macrophages (M0-, M1-, and M2-like) were exposed to Results and discussion: Microscopic analysis illustrated the activation of all cell types tested within 4 h of exposure to

Indexed as

MacrophagesMonocytesToxoplasmaToxoplasmosisAnimalsCattleCytokinesHumansImmunity, InnateTHP-1 CellsCytokinescytokinesearly innate immunityextracellular trapsmononuclear phagocytesToxoplasma gondii

Identifiers

PMID41246354
PMCPMC12611918

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.