ArticleFrontiers in immunology2025
Lactylation-related gene
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The emerging role of lactate in skeletal homeostasis and disorders: Integrated mechanisms and translational opportunities.Journal of orthopaedic translation · 2026Review
- Lactate and lactylation in osteoporosis: pathogenesis, regulation, and future perspectives.Journal of bone and mineral metabolism · 2026Review
- Hyperoside Attenuates Lupus Nephritis-Associated Mesangial Cell Apoptosis via the P53/XAF1 Pathway: Integrative Bioinformatics and In Vitro Validation.Journal of inflammation research · 2026Article
- Commentary: Lactylation-related geneFrontiers in immunology · 2025Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to systematically identify key differentially expressed genes (DEGs) associated with lysine lactylation in osteoporosis and to explore their potential roles in disease pathogenesis from a dual perspective of metabolic and immune regulation, thereby providing a theoretical basis for targeted therapeutic strategies. Methods: Five osteoporosis-related gene expression microarray datasets and one single-cell RNA-sequencing dataset were integrated from the GEO database. A lactylation-related gene panel comprising 1,347 genes was used to construct a screening framework. Batch effect correction, differential expression analysis, GO/KEGG enrichment, CIBERSORT-based immune infiltration, and GSEA/GSVA functional annotation were performed. A total of 113 combinations of machine learning models were applied to identify key genes. Single-cell UMAP clustering and CellChat-based intercellular communication analysis were conducted to further characterize the findings. Results: A total of 37 lactylation-related DEGs were identified, mainly enriched in metabolic and inflammatory pathways. Among them, Conclusion:
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