Evidence map›Paper›PMID 41246284›Full record

ArticleCurrent research in microbial sciences2025

The interactions between psychological stress, gut microbiota, and fecal metabolites: A longitudinal multi-omics study in Chinese adolescents.

Chenghai Yang, Meng Lv, Ying Li, Yafang He, Shunming Zhang, Gong Zhang, Jiao Lan, Zihan Guo, Yuan Cheng, Yuting Yang and 3 more

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Article in Current research in microbial sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chenghai YangSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Meng LvChengdu Aidea Pharmaceutical Technology Co. Ltd, Chengdu, Sichuan, China.
Ying LiDepartment of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yafang HeSpecAlly Life Technology Co., Ltd., Wuhan, Hubei, China.
Shunming ZhangSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Gong ZhangMOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China.
Jiao LanShiquan County Hospital, Ankang, China.
Zihan GuoSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yuan ChengSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yuting YangSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Jintao SunSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Lu MaSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Lei ZhangPhase I clinical trial research ward, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study investigated the bidirectional associations between psychological stress, gut microbiota, and fecal metabolites in a cohort of Chinese adolescents using a multi-omics approach. Methods: Baseline fecal samples from 124 adolescents were subjected to 16S rRNA gene amplicon sequencing, with 51 participants providing samples for metagenomic sequencing and untargeted metabolomics at baseline and follow-up. Psychological stress was assessed via the Adolescent Self-Rating Life Events Checklist. Results: After covariates adjustment, baseline total stress was associated with depleted alpha- and beta-diversity and abundances of the genera Conclusions: This study suggests that psychological stress is associated with specific gut microbes and lipid metabolites change, and in turn, specific metabolites contribute to psychological stress change. These findings provide insights into bidirectional interactions between psychological stress and gut microbiota in adolescents.

Indexed as

Chinese adolescentsFecal metabolitesGut microbiotaPsychological stress

Identifiers

PMID41246284
PMCPMC12612998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.