Evidence map›Paper›PMID 41246275›Full record

ArticleFrontiers in veterinary science2025

Quercetin promotes production of secondary hair follicle stem cells in cashmere goat: a mechanistic study.

Wei Lian, Guoqing Jiang, Xueyong Wu, Yadong Gao, Kun Cui, Lei Zhu, Ziyang Xu, Xiao Zhang, Jiawei Wang, Mingli Peng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Tri-Culture Fermentation of Neem (Plants (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei Lian *Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Guoqing Jiang *Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Xueyong WuKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Yadong GaoKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Kun CuiKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Lei ZhuKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Ziyang XuKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Xiao ZhangKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Jiawei WangKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Mingli PengKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Rui DingKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Fei HaoKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Dongjun LiuKey Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study investigated the effects of quercetin on the proliferation and apoptosis of secondary hair follicle stem cells (SHFSCs) isolated from Arbas cashmere goats. Methods: SHFSCs were treated with varying quercetin concentrations. CCK-8, EdU assays, and flow cytometry analyses were performed to assess cell proliferation and apoptosis. Transcriptome analyses were used to identify differentially expressed genes and enriched signaling pathways. Results: Treatment with 10 μg/mL quercetin for 48 h significantly promoted cell proliferation. The proportion of S-phase cells increased from 15.5% to 21.2%, and the mRNA and protein levels of PCNA and TERT were upregulated. Quercetin inhibited apoptosis by downregulating BAX, TP53, and CASP3, upregulating BCL2, and reducing the number of late apoptotic cells. Mechanistically, quercetin activated the PI3K-Akt, Wnt, and TGF-β signaling pathways, upregulated CCND1 and CDK4 expression, improved mitochondrial membrane potential, reduced ROS levels, and promoted VEGF, FGF, and HGF secretion. Transcriptome analyses revealed that differentially expressed genes were enriched in translational processes, insulin-like growth factor binding, and proliferation-related signaling pathways. Conclusion: Quercetin promotes SHFSC proliferation and inhibits apoptosis through multiple pathways, providing a potential regulatory strategy for improving cashmere production in goats.

Indexed as

antioxidationapoptosiscashmere goatcell proliferationhair follicle stem cellquercetinRNA-Seq

Identifiers

PMID41246275
PMCPMC12616863

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.