Evidence map›Paper›PMID 41246243›Full record

ReviewThe Pan African medical journal2025

[Specific features of multisystem inflammatory syndrome in adults related to SARS-CoV-2].

Fatma Medhioub Kaaniche, Farah Zouari, Salma Jerbi, Ines Dahech, Arij Abdellatif, Yoser Ben Taher, Wiem Feki, Zina Hakim, Sondes Briki, Dorsaf Dlensi and 1 more

Abstract readEnglish AbstractReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Pan African medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fatma Medhioub KaanicheService Universitaire de Réanimation, Hôpital Régional Mahres, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
Farah ZouariService Universitaire de Réanimation, Hôpital Régional Mahres, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
Salma JerbiService Universitaire de Réanimation, Hôpital Régional Mahres, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
Ines DahechService Universitaire de Réanimation, Hôpital Régional Mahres, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
Arij AbdellatifService Universitaire de Réanimation, Hôpital Régional Mahres, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
Yoser Ben TaherService Universitaire de Réanimation, Hôpital Régional Mahres, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
Wiem FekiService de Radiologie, Centre Hospitalier Universitaire Hédi Chaker, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
Zina HakimUnité de Médecine de Travail, Hôpital Régional Mahres, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
Sondes BrikiService de Maxillofacial, Centre Hospitalier Universitaire Habib Bourguiba, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
Dorsaf DlensiService Universitaire de Réanimation, Hôpital Régional Mahres, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
Rania AllalaService Universitaire de Réanimation, Hôpital Régional Mahres, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multisystem inflammatory syndrome in adults (MIS-A) is a rare and severe entity occurring after SARS-CoV-2 infection, and it is often underrecognized in adults. The purpose of this study is to describe the clinical, paraclinical, therapeutic, and prognostic characteristics of MIS-A through a structured review of the literature. A search was conducted in PubMed, Scopus, and Web of Science databases up to May 2024. Articles included were clinical case reports or case series of MIS-A in adults. Eighteen (18) articles were included. MIS-A mainly manifests as persistent fever, multiorgan involvement, marked inflammatory response, and frequently negative SARS-CoV-2 PCR but positive serology. Treatment is based on immunoglobulins, corticosteroids, and, in some cases, anti-IL-6 therapy. Although rare, MIS-A represents a medical emergency to be considered in the aftermath of COVID-19 infection, even in asymptomatic cases. Diagnosis is based on nonspecific clinical and biological criteria, which makes recognition challenging. Early immunomodulatory treatment can improve prognosis.

Indexed as

COVID-19Systemic Inflammatory Response SyndromeAdrenal Cortex HormonesAdultHumansImmunoglobulinsPrognosisAdrenal Cortex HormonesImmunoglobulinsadultCOVID-19immunoglobulinsMIS-AMultisystem inflammatory syndrome

Identifiers

PMID41246243
PMCPMC12617453

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.