Evidence map›Paper›PMID 41246235›Full record

ReviewTurkish journal of biology = Turk biyoloji dergisi2025

Artificial intelligence in medical and biological research: promise and perils of ChatGPT and DeepSeek in advancing healthcare.

Mahmut Enes Kayaalp, Onur Gültekin, Serhat Akçaalan, Hamit Çağlayan Kahraman, Hüseyin Nevzat Topçu, Gülşah Kavrul Kayaalp

Abstract readReview
In one paragraph

Review in Turkish journal of biology = Turk biyoloji dergisi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahmut Enes KayaalpDepartment of Orthopaedics and Traumatology, University of Health Sciences, İstanbul Fatih Sultan Mehmet Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-9545-7454
Onur GültekinDepartment of Orthopaedics and Traumatology, University of Health Sciences, İstanbul Fatih Sultan Mehmet Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-0836-076X
Serhat AkçaalanDepartment of Orthopaedics and Traumatology, Ankara City Hospital, Ankara, Turkiye.ORCID https://orcid.org/0000-0001-7350-6422
Hamit Çağlayan KahramanDepartment of Orthopaedics and Traumatology, University of Health Sciences, İstanbul Fatih Sultan Mehmet Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0001-6150-9300
Hüseyin Nevzat TopçuDepartment of Orthopaedics and Traumatology, Istanbul Kartal Dr. Lütfi Kırdar City Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0009-0007-2272-0462
Gülşah Kavrul KayaalpDepartment of Paediatric Rheumatology, Pendik Research and Training Hospital, Marmara University, İstanbul, Turkiye.ORCID https://orcid.org/0000-0001-7490-7076

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: Artificial intelligence (AI), particularly large language models (LLMs) such as ChatGPT and DeepSeek, is being increasingly applied in clinical care, research, and education. The aim of this review is to examine how these tools may transform the conduct of medical and biological research and to define their limitations. Materials and methods: A narrative synthesis of the literature was performed, encompassing studies published between 2020 and 2025. Peer-reviewed journals, systematic reviews, and high-impact original research articles were included to ensure an evidence-based overview. The principle applications, validation metrics, and clinical implications across orthopedics, oncology, cardiology, internal medicine, and the biological sciences were analyzed. Results: LLMs demonstrate strong potential in supporting physicians during clinical decision-making, enhancing patient education, and assisting researchers in their work. They are valuable for language-related tasks and for generating structured, clear, and comprehensible content. However, concerns persist regarding data privacy, algorithmic bias, factual accuracy, and excessive dependence on data-driven outputs. Responsible implementation requires safeguards such as human oversight, model transparency, and domain-specific training. Conclusion: AI tools such as ChatGPT, DeepSeek, and similar models are transforming the way healthcare is delivered and studied. Their current capabilities appear highly promising. However, clinicians, technical experts, and policymakers must collaborate to ensure the safe, equitable, effective, and ethical integration of these technologies into real-world healthcare workflows.

Indexed as

Artificial intelligenceChatGPTclinical decision supportDeepSeeklarge language modelsmedical education

Identifiers

PMID41246235
PMCPMC12614363

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.