ArticleEnvironmental science & technology letters2025
High-Throughput Miniaturized Biotransformation Testing Using Activated Sludge Enables Rapid Chemical Persistence Assessment.
Article in Environmental science & technology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Persistence Assessment of Chemicals: Trajectories toward New Approach Methodologies (P-NAMs).Environmental science & technology · 2026Review
- "The Dose Makes the Poison": Relevance of Paracelsus's Principle for Modern Chemical Hazard Assessment with New Approach Methodologies.Environmental science & technology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unprecedented scale and pace of chemical development challenges human and ecosystem health unless new chemicals are developed using safe-by-design approaches. Therefore, tools for efficient environmental persistence assessmentamong other critical assessment capabilitiesare urgently needed, as outlined in the European Commission's Safe and Sustainable by Design (SSbD) framework and the European Chemical Agency (ECHA)'s 2025 report on key regulatory challenges. Current persistence tests require large sample amounts and extended timelines making them unsuitable for early stage chemical development. We developed and validated a miniaturized, higher-throughput biotransformation assay using municipal activated sludge as the source of microbial inoculum. For 33 pesticides and pharmaceuticals, biotransformation rate constants showed strong correlation with large volume controls (R
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