ReviewmicroLife2025
One transcript, two functions: the emerging roles of dual-function RNAs.
Review in microLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bacterial small regulatory RNAs.Nature reviews. Microbiology · 2026Review
- Small proteins in prokaryotes, a fascinating world.microLife · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria use small regulatory RNAs (sRNAs) and small proteins to change gene expression and modulate cellular processes in response to changing environmental conditions. In addition, several transcripts have been reported to combine base-pairing sRNA activities and coding capacity. These transcripts are known as dual-function RNAs. In some cases, the sRNA and the protein operate within the same pathway, while in other cases, they modulate separate processes in the cell. Thereby, dual-function RNAs enable bacteria to adjust their gene expression and physiology at multiple levels, which can have synergistic regulatory effects or help to synchronize the output of cellular pathways. In this review, we summarized the regulatory and physiological roles of dual-function RNAs in bacteria, including their roles in intercellular communication, virulence, stress response, and metabolism. In addition, we discuss open challenges and possible future applications for harnessing dual regulators for precise gene expression control in bacteria.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.