ArticleIndian journal of psychological medicine2025
Open-label Prospective, Interventional Study Assessing Efficacy and Safety of Intramuscular Ketamine for Suicidal Ideation in a Tertiary Care Hospital.
Article in Indian journal of psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study evaluated intramuscular (IM) ketamine's efficacy and safety for rapid suicidal ideation reduction, addressing the critical need for fast-acting interventions in resource-limited settings where intravenous (IV) options are impractical. Methods: We conducted a pre-post-interventional study of IM ketamine (0.5 mg/kg) over one year after approval of the institutional ethics committee. Adult patients with suicidal ideation, as measured by the six-point Montgomery-Åsberg Depression Rating Scale-Suicidal Ideation (MADRS-SI), were included if their MADRS-SI score was >4. Post-injection monitoring of suicidal ideation and adverse effects (A/E) was done after two hours and on Days 1, 3, 7, 14, 21, and 28. A repeat injection of the same dose was given only if the MADRS-SI score became > 4 again. The paired- Results: Thirty-eight patients (mean age: 36.3 years) participated, with 66% diagnosed with major depressive disorder and a mean MADRS-SI score of 5.31. At two hours post-injection, the MADRS-SI score decreased by 4.13 points (78% reduction), with 76% ( Conclusions: IM ketamine (0.5 mg/kg) is effective and safe for the rapid reduction of suicidal ideation.
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