ArticleFrontiers in public health2025
Kipiyecipakiciipe ("coming home"): a study protocol for a multi-method investigation of culturally grounded resilience against substance-use among Shawnee adults.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: American Indian and Alaska Native (AI/AN) peoples bear the highest U.S. burden of substance-use disorder (SUD) and drug-overdose mortality. Mechanistic evidence linking community-defined cultural protective factors to neurobehavioral pathways of SUD risk is virtually absent. Most AI/AN health studies are descriptive and rarely integrate neuroscience. Objectives: The Kipiyecipakiciipe ("coming home") project aims to (i) operationalize Shawnee-defined cultural engagement variables, (ii) test their associations with neurobehavioral markers of reward, decision-making, and self-regulation, and (iii) establish evidence base for tribally guided prevention and recovery strategies. Methods: Guided by community-based participatory research, the three-phase multi-method protocol combines qualitative inquiry, a Community Readiness Assessment (CRA), and multimodal neuroimaging. Discussion: By integrating community insight with state-of-the-art neuroimaging under Tribal governance, this protocol addresses critical knowledge gaps in Indigenous SUD research, models CARE-aligned data stewardship and establishes a transferable framework for culturally grounded precision substance use prevention.
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