Evidence map›Paper›PMID 41246041›Full record

ArticleFrontiers in behavioral neuroscience2025

Oscillations in the prefrontal-hippocampal circuit couple to respiration-related oscillations during all phases of a working memory task.

Sunandha Srikanth, Dylan Le, Yudi Hu, Jill K Leutgeb, Stefan Leutgeb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neural Oscillations in Aversively Motivated Behavior.Frontiers in behavioral neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sunandha SrikanthDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, United States.
Dylan LeDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, United States.
Yudi HuDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, United States.
Jill K LeutgebDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, United States.
Stefan LeutgebDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, United States.

Funding

Memory processing after neuron loss in the entorhinal cortex and hippocampusR01NS086947 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEUTGEB, STEFAN · 2014 to 2024
$3.9M
Dependence of memory on precisely coordinated oscillationsR01NS102915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Stefan Leutgeb · 2017 to 2026
$3.1M
Role of Glutamatergic Neurons in External Globus Pallidus in the Behavioral Deficits in Animal Models of Progressive Dopamine DepletionR01NS121231 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEUTGEB, STEFAN, LIM, BYUNGKOOK · 2021 to 2025
$2.5M
Connectivity and function of microcircuits in the superficial layers of the entorhinal cortexR01NS097772 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEUTGEB, STEFAN, LIM, BYUNGKOOK · 2017 to 2021
$2.0M
Defining the metabolic principles of neuronal network oscillationsR01NS136048 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Gulcin Pekkurnaz · 2024 to 2026
$2.0M
Hippocampal network mechanisms for memory-guided behaviorR01MH119179 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEUTGEB, JILL K · 2019 to 2023
$1.8M
NIMH NIH HHS R01 MH119179NINDS NIH HHS R01 NS086947NINDS NIH HHS R01 NS097772NINDS NIH HHS R01 NS102915NINDS NIH HHS R01 NS121231NINDS NIH HHS R01 NS136048
6 · The paper itself

Abstract

Oscillatory activity is thought to coordinate neural computations across brain regions, and theta oscillations are critical for learning and memory. Because respiration-related oscillations (RROs) in rodents can be identified in the prefrontal cortex (PFC) and the hippocampus in addition to canonical theta oscillations, we asked whether odor-cued working memory may be supported by both of these two oscillations. We first confirmed that RROs were propagated to the hippocampus and PFC and that RRO frequency spans a broad range that partially overlaps with canonical theta frequency. During all task phases, we found coherence between PFC and hippocampus at the RRO frequency, irrespective of whether RROs and canonical theta oscillations overlapped or differed in frequency. In parallel, there was also high coherence across PFC and hippocampus at theta frequency, except that the coupling at theta was weakest during odor sampling. Therefore, long-range coordination between brain regions occurs at more than one oscillation frequency in a working memory task, but the two types of oscillations did not show evidence of conjunctively supporting working memory.

Indexed as

hippocampuslocal field potentialsodor-guided memory taskprefrontal cortexrespiration-related oscillationstheta oscillations

Identifiers

PMID41246041
PMCPMC12611856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.