ArticleFrontiers in cardiovascular medicine2025
Subclinical myocardial dysfunction assessed by cardiac magnetic resonance feature tracking predicts ventricular arrhythmias in early-stage hypertension.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Substantial evidence supports the utility of cardiac magnetic resonance feature tracking (CMR-FT) in evaluating subclinical cardiac dysfunction. This study investigated the clinical value of CMR-derived left ventricular (LV) strain for detecting myocardial impairment in asymptomatic patients with hypertension (HTN) and explored its association with ventricular arrhythmias (VA). Methods: A retrospective analysis included 150 HTN patients [with/without LV hypertrophy (LVH)] and 60 healthy controls. Clinical data and CMR parameters were collected. Conventional LV functional indices and strain parameters-global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS)-were measured and compared across groups. The multivariable regression model was used to identify independent risk factors for VA. Results: Compared with controls, HTN patients showed significantly elevated LV mass index (LVMI) and maximal wall thickness (LVMWT) ( Conclusion: CMR-FT-derived myocardial strain parameters demonstrate high sensitivity in detecting subclinical LV dysfunction in HTN patients. Furthermore, progressive impairment of GCS may serve as an independent risk factor for VA in this population. These findings provide imaging-based evidence to guide early interventions aimed at mitigating cardiac remodeling and arrhythmia development in HTN.
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