Evidence map›Paper›PMID 41245993›Full record

ReviewBurns & trauma2025

Piezo1 and tissue fibrosis: insights into its role and potential for modulation.

Yuxin Lin, Dongsheng Wen, Kai Chen, Zhiang Hu, Chiakang Ho, Yangdan Liu, Zhiyuan Zhou, Ya Gao, Qingfeng Li, Yifan Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. [Research progress on clinical transformation of Piezo1 in osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. A PIEZO-Gated Mechanotransduction Timing Window Governs Scar Commitment in Wound Healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuxin LinDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.
Dongsheng WenDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.
Kai ChenShanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197, Ruijin 2nd Road, Huangpu District, Shanghai 200025, China.
Zhiang HuShanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.
Chiakang HoDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.
Yangdan LiuDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.
Zhiyuan ZhouDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.
Ya GaoDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.
Qingfeng LiDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.ORCID https://orcid.org/0000-0001-7822-618X
Yifan ZhangDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639, Zhizaoju Road, Huangpu District, Shanghai 200011, China.ORCID https://orcid.org/0000-0002-0283-0468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibrosis is a pathological process marked by excessive extracellular matrix deposition, ultimately resulting in irreversible tissue damage. This aberrant process manifests across multiple organs, including the skin, lung, cardiovascular system, liver, kidneys, and eyes. However, the underlying mechanisms driving tissue fibrosis remain incompletely elucidated, and effective therapeutics are still lacking. In recent years, increasing attention has turned toward the contribution of mechanical signals to fibrotic progression. Within this context, the Piezo family of mechanosensitive ion channels, recently identified as key mediators of mechanotransduction, has emerged as a compelling focus of investigation in diverse pathological settings. This review summarizes current evidence on the central role of Piezo1 in orchestrating fibrotic responses across various tissues. Moreover, we examine the application of Piezo1 modulators in experimental models and their potential to modulate fibrosis, thereby informing the development of novel antifibrotic interventions. By integrating mechanobiological insights into the study of fibrosis, this work highlights promising translational avenues for advancing therapeutic strategies and improving clinical outcomes in fibrotic disease.

Indexed as

BiomechanicsExtracellular matrixFibrosisPiezo1

Identifiers

PMID41245993
PMCPMC12616850

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.