ArticleCureus2025
Spontaneous Pregnancy After Isotretinoin Use in a Man After Unsuccessful Microdissection Testicular Sperm Extraction.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a spontaneous pregnancy in the partner of a man with non-obstructive azoospermia and histologically confirmed late maturation arrest following a failed microdissection testicular sperm extraction (micro-TESE). This patient was subsequently treated with isotretinoin for six months and, thereafter, conceived naturally without any assisted reproductive techniques. This case suggests the possibility of improvement in sperm production in men with nonobstructive azoospermia (NOA) despite lack of success with surgical sperm retrieval and implicates isotretinoin as a potential therapeutic agent that is noninvasive and cost-effective. While causality cannot be established from a single case, these findings warrant further investigation in prospective studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.