Evidence map›Paper›PMID 41245888›Full record

ArticleComputational and structural biotechnology journal2025

Distinct IRF6 dysfunction mechanisms in syndromic orofacial clefts: Computational evidence for allosteric versus direct disruption.

Ana Luiza Meneguci Moreira Franco, Deborah Antunes, Ana Clara Rodrigues Moreira Gomes, Bruno Santos de Barros Dias, Henrique Pessoa Ladvocat Cintra, Ana Carolina Ramos Guimarães, Elizeu Fagundes de Carvalho, Fernando Regla Vargas, Flávia Martinez de Carvalho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana Luiza Meneguci Moreira FrancoPrograma de Pós-Graduação em Genética da Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, Centro de Ciências da Saúde, Ilha do Fundão, Rio de Janeiro, 21941-617, Rio de Janeiro, Brazil.
Deborah AntunesLaboratório de Genômica Aplicada e Bioinovações - Instituto Oswaldo Cruz - Fiocruz, Avenida Brasil, 4365 - Manguinhos, Rio de Janeiro, 21040-360, Rio de Janeiro, Brazil.
Ana Clara Rodrigues Moreira GomesLaboratório de Epidemiologia de Malformações Congênitas - Instituto Oswaldo Cruz - Fiocruz, Avenida Brasil, 4365 - Manguinhos, Rio de Janeiro, 21040-360, Rio de Janeiro, Brazil.
Bruno Santos de Barros DiasCentro de Tratamento de Anomalias Craniofaciais da Universidade do Estado do Rio de Janeiro, Avenida Marechal Rondon, 381 - São Francisco Xavier, Rio de Janeiro, 20950-003, Rio de Janeiro, Brazil.
Henrique Pessoa Ladvocat CintraCentro de Tratamento de Anomalias Craniofaciais da Universidade do Estado do Rio de Janeiro, Avenida Marechal Rondon, 381 - São Francisco Xavier, Rio de Janeiro, 20950-003, Rio de Janeiro, Brazil.
Ana Carolina Ramos GuimarãesLaboratório de Genômica Aplicada e Bioinovações - Instituto Oswaldo Cruz - Fiocruz, Avenida Brasil, 4365 - Manguinhos, Rio de Janeiro, 21040-360, Rio de Janeiro, Brazil.
Elizeu Fagundes de CarvalhoLaboratório de Diagnósticos por DNA - Universidade do Estado do Rio de Janeiro, Pavilhão Reitor Haroldo Lisboa da Cunha, Maracanã, Rio de Janeiro, 20550-013, Rio de Janeiro, Brazil.
Fernando Regla VargasPrograma de Pós-Graduação em Genética da Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, Centro de Ciências da Saúde, Ilha do Fundão, Rio de Janeiro, 21941-617, Rio de Janeiro, Brazil.
Flávia Martinez de CarvalhoPrograma de Pós-Graduação em Genética da Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, Centro de Ciências da Saúde, Ilha do Fundão, Rio de Janeiro, 21941-617, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orofacial clefts (OC) are a congenital anomaly typically classified as syndromic or non-syndromic. Among the syndromic cases, Van der Woude syndrome (VWS) and popliteal pterygium syndrome (PPS) are primarily caused by pathogenic variants in

Indexed as

Molecular dynamicsPopliteal pterygium syndromeSyndromic orofacial cleftVan der Woude syndrome

Identifiers

PMID41245888
PMCPMC12615309

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.