ArticleFrontiers in neurology2025
Integrating skeletal muscle index and body roundness index for predicting functional outcomes in acute stroke patients: a prospective observational study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: After stroke, many patients experience dysphagia, anorexia, and metabolic stress, which may lead to malnutrition and accelerated loss of skeletal muscle mass. Sarcopenia and body fat distribution abnormalities significantly impact functional outcomes in acute stroke patients. While the skeletal muscle index (SMI) and body roundness index (BRI) have been studied individually, their combined predictive value for poor prognosis remains unclear. This study evaluates the integration of SMI and BRI for predicting unfavorable functional outcomes in acute stroke patients. Methods: A single-center, prospective cohort study was conducted on 123 acute ischemic stroke patients admitted within 3 days of onset. In this acute cohort, standardized strength/performance testing at admission was not feasible due to hemiparesis. Therefore, low skeletal muscle mass (L3-SMI) was used as the primary exposure. SMI was measured at the L3 vertebra using MRI, with sex-specific thresholds informed by EWGSOP2/AWGS muscle-quantity criteria. BRI was calculated based on waist circumference and height. Functional outcomes were assessed at 90 days post-discharge using the modified Rankin scale (mRS). Multivariate logistic regression and receiver operating characteristic (ROC) analyses were used to evaluate the independent and combined predictive abilities of SMI and BRI. Results: Patients with sarcopenia had significantly lower SMI (33.722 ± 3.307 cm Conclusion: The integration of SMI and BRI suggests a promising, hypothesis-generating model for identifying patients at risk of unfavorable outcomes after acute stroke, which may support early recognition and individualized management. These exploratory findings require further validation in larger, multicenter studies to confirm their robustness and generalizability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.