SynthesisFrontiers in neurology2025
Diagnostic utility of neurogenic biomarkers in differentiating sepsis with and without associated encephalopathy: a systematic review and meta-analytic approach.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background: Sepsis-associated encephalopathy (SAE) is a frequent complication of sepsis, manifesting as acute brain dysfunction and often resulting in persistent cognitive deficits, neurological impairment, and increased mortality. Timely and accurate diagnosis of SAE is essential to guide therapeutic decisions and improve clinical outcomes. In recent years, neurogenic biomarkers have emerged as potential serum-based indicators for the diagnosis and progression monitoring of SAE. Methods: A comprehensive search of PubMed/MEDLINE, Embase, the Cochrane Library, Web of Science, and Scopus was conducted from inception to 30 April 2025. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Results: Forty-seven studies (50 arms) were included. Random-effects analysis revealed significant differences in serum NSE levels between SAE and NE adult patients (WMD = 6.82; 95% CI: 5.43, 8.21; Conclusion: Elevated serum levels of neurogenic biomarkers may serve as potential predictors of SAE and are associated with increased mortality in septic patients. These biomarkers show promise as reliable, minimally invasive tools for diagnosis and longitudinal monitoring of SAE. However, these findings should be interpreted with caution due to substantial heterogeneity across the included studies.
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